Many human diseases are caused by cellular and molecular changes in signal transduction and gene regulatory pathways as a consequence of kinetic exposure of humans to harmful environmental conditions. However, when we try to understand molecular alternations that appear in disease cells, almost all biological studies today are performed in environments that are constant over time and may not represent physiologically relevant conditions. In addition, even within a group of individuals diagnosed with the same condition, the disease outcome and response to treatment at the whole body, organ or cellular level can vastly differ. However, because most studies are based on population measurements, they assume that all cells of a specific type behave identical. To address these limitations, my lab aims to understand fundamental mechanisms of signal transduction and gene expression in normal and disease physiology in the context of kinetics and variability. We do so by applying a quantitative framework to broad biological questions in model organisms and in healthy and diseased tissue. We combine a series of single cell, single molecule and genome-wide approaches and complement these quantitative assays with in-depth computational data analysis, genetics, molecular biology, chemical profiling and single cell predictive computational modeling.
Specific questions of interest are:
How do individual cells perceive physiologically relevant environments?
How do proteins generate dynamic behavior within a single cell?
How do cells regulate genes in physiologically relevant dynamic and stochastic environments?
How to computationally model and predict single-cell behavior to gain novel biological insight?
May 2020 – Insights in Signaling Dynamics and Encoding (InSiDE 2020), College of Biological Sciences, UC Davis, Davis, CA
July 2019 – FASEB conference on Protein Kinases and Protein Phosphorylation – Mechanisms to Therapeutics, Palm Springs, CA
June 2019 – NSF workshop: Finding Your Inner Modeler, University of Alabama at Birmingham, AL
February 2019 – LSU Health Sciences Center, New Orleans, LA
November 2018 – Molecular Biophysics Training Program and Center for Structural Biology Seminar Series, Vanderbilt University, Nashville, TN, USA
August 2018 – Cold Spring Harbor Laboratory meeting on Single Biomolecules, Cold Spring Harbor, NY
July 2018 – International Society for Computational Biology (ISCB), Chicago, IL
June 2018 – EMBO Conference, Gene transcription in yeast, Sant Feliu de Guixols, Spain
April 2018 – Center for Quantitative Systems Biology, Vanderbilt University, Nashville, TN, USA
February 2018 – Colloquium, Department of Physics, Vanderbilt University, Nashville, TN, USA
July 25-28, 2017 – The Eleventh q-bio Conference, Rutgers University, New Brunswick, New Jersey, USA
March 13-17, 2017 – American Physical Society Meeting, New Orleans, USA
February 11-15, 2017 – American Biophysical Society Meeting, New Orleans, USA
December 15, 2016 – Seminar, Department of Bionanoscience, TU-Delft, Delft, Netherlands
December 14, 2016 – Seminar, Hubrecht Institute, Utrecht, Netherlands
December 12, 2016 – Colloquium, AMOLF, Amsterdam, Netherlands
December 9, 2016 – van der Waals Colloquium, Department of Physics, Leiden University, Leiden, Netherlands
October 28, 2016 – Seminar, Department of Cell & Systems Biology, University of Toronto, Toronto, Canada
September 30, 2016 – Colloquium, Department of Mathematics and Statistics, Georgia State University, Atlanta, USA
September 29, 2016 – Seminar, Department of Physics, Emory University, Atlanta, USA
July 27-30, 2016 – Q-Bio Conference, Nashville, USA
June 11-16, 2016 – EMBO Conference, Gene transcription in yeast, Sant Feliu de Guixols, Spain
June 9, 2016 – Biological Colloquium, Technical University Darmstadt, Darmstadt, Germany
June 6, 2016 – Physical Colloquium, Ulm University, Ulm, Germany
February 15, 2016 – Winter Q-Bio Conference, Hawaii, USA
April 20, 2015 – NIH Single Cell Analysis Program Investigators Meeting, NIH, Bethesda, MD, USA
April 13, 2015 – VICC Signal Transduction mini-retreat, School of Medicine, Vanderbilt University, Nashville, TN, USA
February 25, 2015 – Center for Systems Biology, Duke University, Durham, NC, USA
February 24, 2015 – Department of Pharmacology, University of North Carolina, Chapel Hill, NC, USA
December 15-17, 2014 – High Risk-High Reward Research Symposium, NIH, Bethesda, MD, USA
December 12, 2014 – NIH, Bethesda, MD, USA
December 10, 2014 – Department of Pharmacology, School of Medicine, Vanderbilt University, Nashville, TN, USA
November 13-14, 2014 – Department of Chemical and Biological Engineering, Colorado State University, Fort Collins, CO, USA
October 2, 2014 – Retreat, Department of Molecular Physiology and Biophysics, School of Medicine, Vanderbilt University, Nashville, TN, USA
September 25-26, 2014 – Department of Molecular Biosciences, Northwestern University, Evanston, IL, USA
June 2020 – Check out our new paper
May 2020 – Blythe was selected for a BIDS training grant slot.
April 2020 – Blythe Hospelhorm joins our lab as a graduate student.
March 2020 – Jason won an NSF predoctoral fellowship.
February 2020–Alexander gave a talk at the Winter Q-bio conference in Hawaii.
February 2020 – Rama Ali joins our lab as a postdoc.
December 2019 – Ben presented a poster at the ASCB meeting in Washington, DC.
October 2019–Alexander presented a poster at the Symposium on Multiscale Cell Fate at UCI.
October 2019– Welcome Amy to her second rotation.
October 2019 – Check out our new paper
September 2019 – Welcome Elena and Blythe to their first rotation.
August 2019 – Our new microscope got installed.
August 2019 – Jason presented a poster at the CSH Meeting on Mechanisms of Eukaryotic Transcription.
August 2019 -Alexander presented a poster at the CSH Meeting on Cell Death.
July 2019 – Alexander’s and Hossein’s paper got published in Scientific Reports.
July 2019 – Ben’s paper got published in Scientific Reports.
July 2019 – We are part of the Helmsley Charitable Trust Gut Cell Atlas.
July 2019 – Amanda and Joseph presented posters at the FASEB conference Protein Kinases and Protein Phosphorylation Conference: Mechanisms to Therapeutics.
June 2019 – Neuert lab participates in the NSF workshop: Finding Your Inner Modeler.
June 2019 – Guoliang’s paper got published in Scientific Data.
June 2019 – Jason Hughes was selected for a ITED training grant slot.
May 2019 – Joseph Cleland was selected for a MBTP training grant slot.
May 2019 – Jason Hughes and Joseph Cleland join our lab as graduate students.
April 2019 – Hossein gave a talk at the CSH meeting on Cellular Dynamics & Models.
March 2019 – Alexander presented a poster at the CSH Meeting on Systems Immunology.
March 4, 2019 – Welcome Robert and Steven to their lab rotation.
January 3, 2019 – Welcome Joseph to his lab rotation.
September 27, 2018 – We are part of the Cancer Moonshot award to help map tumor progression.
September 10, 2018 – Amanda’s paper got published in eLife.
August 21, 2018 – Welcome Jason to his lab rotation.
August 17, 2018 – Checkout the coverage of our PNAS paper in VUMC Aliquots.
July 18, 2018 – Alexander Thiemicke was awarded an AHA predoctoral fellowship.
October 21, 2017 – Dr. Guoliang Li has accepted an Assistant Professor position at Sichuan University in Chengdu, China starting January 1, 2018.
September 15, 2017 – Dustin Rogers has accepted a position as Research Associate I at Pierian Biosciences in Franklin, TN.
September 8, 2017 – Drs. Amanda Johnson and Hossein Jashnsaz won the second and third place for best poster presentation at the PDB retreat.
August 1, 2017 – Amanda Johnson was selected for a slot on the Ion Channel and Transporter Biology Training Program.
August 1, 2017 – Amanda Johnson joins our lab as a postdoc.
July 31, 2017 – The Neuert lab is moving to 723 LH.
June 1, 2017 – Dr. Hossein Jashnsaz joins our lab as a postdoc.
May 1, 2017 – Rob Markowitz is joining us for the summer.
August 1, 2016 – Zachary Fox from Brian Munsky’s lab is visiting our lab for one month.
July 25, 2016 – Our paper has been accepted for publication.
June 27, 2016 – Alexander’s paper from his masters thesis got published.
May 23, 2016 – Arunabh Signh joins our lab as a VUSRP fellow and undergraduate researcher.
August 21, 2015 – Gregor was appointed Assistant Professor of Pharmacology.
June 11, 2015 – Our second paper has been accepted for publication.
May 20, 2015 – Benjamin Kesler was selected for a MBTP training grant slot.
April 16, 2015 – Benjamin Kesler joins our lab as graduate student.
April 7, 2015 – Our first paper has been accepted for publication.
February 12, 2015 – We have joined the Vanderbilt-Ingram Cancer Center.
November 2014 – Our lab submitted its first paper.
October 10, 2014 – Our lab is featured in the Vanderbilt Reporter and Research News
September 19, 2014 – Gregor was selected for an 2014 NIH Director’s New Innovator Award
August 1, 2014 – Alexander Thiemicke joins our lab as graduate student.
May 1, 2014 – Dustin Rogers joins our lab as research technician.
February 2, 2013 – Our research is published in SCIENCE
December 1, 2012 – Guoliang Li joins our lab as post-doctoral fellow.
September 9, 2012 – Our research is published in CELL
August 31, 2012 – Our lab opens.
April 4, 2012 – Our research is published in SCIENCE
February 2, 2012 – Our research is published in MOLECULAR CELL
Funding and Support