Golgi as an MTOC: making microtubules for its own good.
AUTHORS
Zhu| Kaverina
X| IXiaodong| Irina .
Histochemistry and cell biology. 2013 9 ; 140(3).
361-7
- PMID: 23821162[PubMed].
- PMCID: PMC3748218.
- NIHMSID: NIHMS501620
ABSTRACT
In cells, microtubules (MTs) are nucleated at MT-organizing centers (MTOCs). The centrosome-based MTOCs organize radial MT arrays, which are often not optimal for polarized trafficking. A recently discovered subset of non-centrosomal MTs nucleated at the Golgi has proven to be indispensable for the Golgi organization, post-Golgi trafficking and cell polarity. Here, we summarize the history of this discovery, known molecular prerequisites of MT nucleation at the Golgi and unique functions of Golgi-derived MTs.
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