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Golgi as an MTOC: making microtubules for its own good.


AUTHORS

Zhu| Kaverina X| IXiaodong| Irina . Histochemistry and cell biology. 2013 9 ; 140(3). 361-7

ABSTRACT

In cells, microtubules (MTs) are nucleated at MT-organizing centers (MTOCs). The centrosome-based MTOCs organize radial MT arrays, which are often not optimal for polarized trafficking. A recently discovered subset of non-centrosomal MTs nucleated at the Golgi has proven to be indispensable for the Golgi organization, post-Golgi trafficking and cell polarity. Here, we summarize the history of this discovery, known molecular prerequisites of MT nucleation at the Golgi and unique functions of Golgi-derived MTs.



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