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Kaverina Lab

Kaverina Lab Publications

2023

Fye Margret A , Kaverina Irina , Insulin secretion hot spots in pancreatic β cells as secreting adhesions Front Cell Dev Biol. 2023 May 26;
Ho Kung-Hsien , Jayathilake Anissa , Yagan Mahircan , Nour Aisha , Osipovich Anna B , Magnuson Mark A , Gu Guoqiang , Kaverina Irina , CAMSAP2 localizes to the Golgi in islet β-cells and facilitates Golgi-ER trafficking iScience. 2023 Jan 7;
Rodgers N C , Lawrence E J , Sawant A V , Efimova N , Gonzalez-Vasquez G , Hickman T T , Kaverina I , Zanic M , CLASP2 facilitates dynamic actin filament organization along the microtubule lattice Mol Biol Cell. 2023 Mar 1;

2022

Frye Keyada B , Zhu Xiaodong , Khodjakov Alexey , Kaverina Irina , Unbiased Quantification of Golgi Scattering and Golgi-Centrosome Association Methods Mol Biol. 2022 Dec 14;
Narasimhan Shwetha , Holmes William R , Kaverina Irina , Merging of ventral fibers at adhesions drives the remodeling of cellular contractile systems in fibroblasts Cytoskeleton. 2022 Sep 5;
Bracey Kai M , Gu Guoqiang , Kaverina Irina , Microtubules in Pancreatic β Cells: Convoluted Roadways Toward Precision 2022 Jul 8;
Yang Liu , Fye Margret A , Yang Bingyuan , Tang Zihan , Zhang Yue , Haigh Sander , Covington Brittney A , Bracey Kai M , Taraska Justin W , Kaverina Irina , Qu Shen , Chen Wenbiao , Genome-wide CRISPR screen identified a role for commander complex mediated ITGB1 recycling in basal insulin secretion 2022 Jul 11;

2021

Trogden P , Lee Justin , Bracey M , Ho Kung-Hsien , McKinney Hudson , Zhu Xiaodong , Arpag Goker , Folland G , Osipovich B , Magnuson A , Zanic Marija , Gu Guoqiang , Holmes R , Kaverina Irina , Microtubules regulate pancreatic β-cell heterogeneity via spatiotemporal control of insulin secretion hot spots Elife. 2021 Nov 16;
Hauke* Lara , Narasimhan* Shwetha , Primeßnig Andreas , Kaverina Irina , Rehfeldt Florian , A Focal Adhesion Filament Cross-correlation Kit for fast, automated segmentation and correlation of focal adhesions and actin stress fibers in cells PLoS One. 2021 Sep 10; (16(9):e0250749).
Hu Ruiying , Zhu Xiaodong , Yuan Mingyang , Ho Kung-Hsien , Kaverina Irina , Gu Guoqiang , Microtubules and Gαo-signaling modulate the preferential secretion of young insulin secretory granules in islet β cells via independent pathways 2021 Jul 22; (16(7): e0241939).

2020

Yang Xiaodun , Graff Sarah M , Heiser Cody N , Ho Kung-Hsien , Chen Bob , Simmons Alan J , Southard-Smith Austin N , David Gregory , Jacobson David A , Kaverina Irina , Wright Christopher V E , Lau Ken S , Gu Guoqiang , Coregulator Sin3a Promotes Postnatal Murine β-Cell Fitness by Regulating Genes in Ca 2+ Homeostasis, Cell Survival, Vesicle Biosynthesis, Glucose Metabolism, and Stress Response Diabetes. 2020 Jun ; (69(6)). 1219–1231
Hu Ruiying , Walker Emily , Huang Chen , Xu Yanwen , Weng Chen , Erickson Gillian E , Golovin Anastasia , Yang Xiaodun , Brissova Marcella , Kaverina Irina , Appakalai Balamurugan N , Wright Christopher V E , Li Yan , Stein Roland , Gu Guoqiang , Myt Transcription Factors Prevent Stress-Response Gene Overactivation to Enable Postnatal Pancreatic β Cell Proliferation, Function, and Survival 2020 May 18; (53(4)). 390-405
Thoppil* Roslin J , Sanders* Anna AWM , Kaverina Irina , Detection of Microtubule Nucleation Hotspots at the Golgi Cytoskeleton Dynamics . 2020 ; 179-189
Ho Kung-Hsien , Yang Xiaodun , Osipovich Anna B , Cabrera Over , Hayashi Mansuo L , Magnuson Mark A , Gu Guoqiang , Kaverina Irina , Glucose Regulates Microtubule Disassembly and the Dose of Insulin Secretion Via Tau Phosphorylation Diabetes.. 2020 Jun 15; 69 (8).
Frye Keyada , Renda Fioranna , Fomicheva Maria , Zhu Xiaodong , Gong Lisa , Khodjakov Alexey , Kaverina Irina , Cell Cycle-Dependent Dynamics of the Golgi-Centrosome Association in Motile Cells Cells.. 2020 Apr 25; 9 (5).
Bracey* Kai M , Ho* Kung-Hsien , Yampolsky Dmitry , Gu Guogiang , Kaverina Irina , Holmes William R , Microtubules Regulate Localization and Availability of Insulin Granules in Pancreatic Beta Cells. Biophysical Journal . 2020 Jan 7; (118(1)). 193-206.

2019

Trogden Kathryn , Zhu Xiaodong , Lee Justin , Wright Christopher , Gu Guoqiang , Kaverina Irina , Regulation of Glucose-Dependent Golgi-Derived Microtubules by cAMP/EPAC2 Promotes Secretory Vesicle Biogenesis in Pancreatic β Cells. Current Biology . 2019 Jul 22; 29 (14). 2339-2350

2018

Tonucci FM , Ferretti A , Almada E , Cribb P , Vena R , Hidalgo F , Favre C , Tyska MJ , Kaverina I , Larocca MC , Microtubules regulate brush border formation. Journal of Cell Physiology. 2018 Feb ; (233(2)). 1468-1480

2017

Sanders AAWM , Chang K , Zhu X , Thoppil RJ , Holmes WR , Kaverina I , Nonrandom γ-TuNA-dependent spatial pattern of microtubule nucleation at the Golgi. Molecular Biology of the Cell. 2017 Nov 7; (28(23)). 3181-3192

2016

Arnette C , Frye K , Kaverina I , Microtubule and Actin Interplay Drive Intracellular c-Src Trafficking. PLoS one. 2016 Feb 11; (11(2)). e0148996
Zhu X , Efimova N , Arnette C , Hanks SK , Kaverina I , Podosome dynamics and location in vascular smooth muscle cells require CLASP-dependent microtubule bending Cytroskeleton(Hoboken). 2016 Jun ; (73(6)). 300-15

2015

Cleghorn| Branch| Kook| Arnette| Bulus| Zent| Kaverina| Gurevich| Weaver| Gurevich WM| KM| S| C| N| R| I| EV| AM| VV , Arrestins regulate cell spreading and motility via focal adhesion dynamics. Molecular Biology of the Cell. 2015 Feb 15; 26 (4). 622-35
Maki| Grimaldi| Fuchigami| Kaverina| Hayashi T| AD| S| I| I , CLASP2 Has Two Distinct TOG Domains That Contribute Differently to Microtubule Dynamics Journal of Molecular Biology. 2015 Jul 17; 427 (14). 2379-95
Tonucci| Hidalgo| Ferretti| Almada| Favre| Goldenring| Kaverina| Kierbel| Larocca FM| F| A| E| C| JR| I| A| MC , Centrosomal AKAP350 and CIP4 act in concert to define centrosome/Golgi polarity in migratory cells. Journal of Cell Science. 2015 Jul 24;
Grimaldi| Zanic| Kaverina AD| M| I , Encoding the microtubule structure: Allosteric interactions between the microtubule +TIP complex mas… Cell cycle (Georgetown, Tex.). 2015 ; 14 (9). 1375-8
Zhu X, Hu R, Brissova M, Stein RW, Powers AC, Gu G, Kaverina I , Microtubules Negatively Regulate Insulin Secretion in Pancreatic β Cells. Developmental Cell. 2015 Sep ; 34 (28). 656-68
Sanders| Kaverina AA| I , Nucleation and Dynamics of Golgi-derived Microtubules. Frontiers in neuroscience. 2015 Nov ; 9 431

2014

Arnette| Efimova| Zhu| Clark| Kaverina C| N| X| GJ| I , Microtubule segment stabilization by RASSF1A is required for proper microtubule dynamics and Golgi i… Molecular biology of the cell. 2014 Mar ; 25 (6). 800-10
Efimova| Grimaldi| Bachmann| Frye| Zhu| Feoktistov| Straube| Kaverina N| A| A| K| X| A| A| I , Podosome-regulating kinesin KIF1C translocates to the cell periphery in a CLASP-dependent manner. Journal of cell science. 2014 Oct 24;
Grimaldi| Maki| Fitton| Roth| Yampolsky| Davidson| Svitkina| Straube| Hayashi| Kaverina AD| T| BP| D| D| MW| T| A| I| I , CLASPs are required for proper microtubule localization of end-binding proteins. Developmental cell. 2014 Aug 11; 30 (3). 343-52

2013

Grimaldi| Fomicheva| Kaverina AD| M| I , Ice recovery assay for detection of Golgi-derived microtubules. Methods in cell biology. 2013 Dec ; 118 401-15
Zhu| Kaverina X| I , Golgi as an MTOC: making microtubules for its own good. Histochemistry and cell biology. 2013 Sep ; 140 (3). 361-7
Alieva| Zemskov| Smurova| Kaverina| Verin IB| EA| KM| I| AD , The leading role of microtubules in endothelial barrier dysfunction: disassembly of peripheral micro… Journal of cellular biochemistry. 2013 Oct ; 114 (10). 2258-72
Maia| Zhu| Miller| Gu| Maiato| Kaverina AR| X| P| G| H| I , Modulation of Golgi-associated microtubule nucleation throughout the cell cycle. Cytoskeleton (Hoboken, N.J.). 2013 Jan ; 70 (1). 32-43

2012

Maia| Garcia| Kabeche| Barisic| Maffini| Macedo-Ribeiro| Cheeseman| Compton| Kaverina| Maiato AR| Z| L| M| S| S| IM| DA| I| H , Cdk1 and Plk1 mediate a CLASP2 phospho-switch that stabilizes kinetochore-microtubule attachments. The Journal of cell biology. 2012 Oct 15; 199 (2). 285-301
Vinogradova| Paul| Grimaldi| Loncarek| Miller| Yampolsky| Magidson| Khodjakov| Mogilner| Kaverina T| R| AD| J| PM| D| V| A| A| I , Concerted effort of centrosomal and Golgi-derived microtubules is required for proper Golgi complex … Molecular biology of the cell. 2012 Mar ; 23 (5). 820-33

2011

Zhu| Kaverina X| I , Quantification of asymmetric microtubule nucleation at subcellular structures. Methods in molecular biology (Clifton, N.J.). 2011 ; 777 235-44
Kaverina| Straube I| A , Regulation of cell migration by dynamic microtubules. Seminars in cell & developmental biology. 2011 Dec ; 22 (9). 968-74
Sung| Zhu| Kaverina| Weaver BH| X| I| AM , Cortactin controls cell motility and lamellipodial dynamics by regulating ECM secretion. Current biology : CB. 2011 Sep 13; 21 (17). 1460-9
Zhu| Wang| Moriguchi| Liow| Ahmed| Kaverina| Murata-Hori X| J| K| LT| S| I| M , Proper regulation of Cdc42 activity is required for tight actin concentration at the equator during … Experimental cell research. 2011 Oct 1; 317 (16). 2384-9

2010

Donato| Ryzhova| Meenderink| Kaverina| Hanks DM| LM| LM| I| SK , Dynamics and mechanism of p130Cas localization to focal adhesions. The Journal of biological chemistry. 2010 Jul 2; 285 (27). 20769-79
Meenderink| Ryzhova| Donato| Gochberg| Kaverina| Hanks LM| LM| DM| DF| I| SK , P130Cas Src-binding and substrate domains have distinct roles in sustaining focal adhesion disassemb… PloS one. 2010 ; 5 (10). e13412

2009

Moynihan| Pooley| Miller| Kaverina| Bader KL| R| PM| I| DM , Murine CENP-F regulates centrosomal microtubule nucleation and interacts with Hook2 at the centrosom… Molecular biology of the cell. 2009 Nov ; 20 (22). 4790-803
Miller| Folkmann| Maia| Efimova| Efimov| Kaverina PM| AW| AR| N| A| I , Golgi-derived CLASP-dependent microtubules control Golgi organization and polarized trafficking in m… Nature cell biology. 2009 Sep ; 11 (9). 1069-80
Kolobova| Efimov| Kaverina| Rishi| Schrader| Ham| Larocca| Goldenring E| A| I| AK| JW| AJ| MC| JR , Microtubule-dependent association of AKAP350A and CCAR1 with RNA stress granules. Experimental cell research. 2009 Feb 1; 315 (3). 542-55
Vinogradova| Miller| Kaverina T| PM| I , Microtubule network asymmetry in motile cells: role of Golgi-derived array. Cell cycle (Georgetown, Tex.). 2009 Jul 15; 8 (14). 2168-74
Efimov| Kaverina A| I , Significance of microtubule catastrophes at focal adhesion sites. Cell adhesion & migration. 2009 Jul 27; 3 (3). 285-7

2008

Efimov| Schiefermeier| Grigoriev| Ohi| Brown| Turner| Small| Kaverina A| N| I| R| MC| CE| JV| I , Paxillin-dependent stimulation of microtubule catastrophes at focal adhesion sites. Journal of cell science. 2008 Jan 15; 121 (Pt 2). 196-204
Siesser| Meenderink| Ryzhova| Michael| Dumbauld| García| Kaverina| Hanks PM| LM| L| KE| DW| AJ| I| SK , A FAK/Src chimera with gain-of-function properties promotes formation of large peripheral adhesions … Cell motility and the cytoskeleton. 2008 Jan ; 65 (1). 25-39
Broussard| Webb| Kaverina JA| DJ| I , Asymmetric focal adhesion disassembly in motile cells. Current opinion in cell biology. 2008 Feb ; 20 (1). 85-90

2007

Efimov| Kharitonov| Efimova| Loncarek| Miller| Andreyeva| Gleeson| Galjart| Maia| McLeod| Yates| Maiato| Khodjakov| Akhmanova| Kaverina A| A| N| J| PM| N| P| N| AR| IX| JR| H| A| A| I , Asymmetric CLASP-dependent nucleation of noncentrosomal microtubules at the trans-Golgi network. Developmental cell. 2007 Jun ; 12 (6). 917-30

2006

Harris| Govindan| Yamamoto| Schwartz| Kaverina| Greenstein JE| JA| I| J| I| D , Major sperm protein signaling promotes oocyte microtubule reorganization prior to fertilization in C… Developmental biology. 2006 Nov 1; 299 (1). 105-21

2005

Rid| Schiefermeier| Grigoriev| Small| Kaverina R| N| I| JV| I , The last but not the least: the origin and significance of trailing adhesions in fibroblastic cells. Cell motility and the cytoskeleton. 2005 Jul ; 61 (3). 161-71

2003

Kaverina| Stradal| Gimona I| TE| M , Podosome formation in cultured A7r5 vascular smooth muscle cells requires Arp2/3-dependent de-novo a… Journal of cell science. 2003 Dec 15; 116 (Pt 24). 4915-24

2002

Kaverina| Krylyshkina| Beningo| Anderson| Wang| Small I| O| K| K| YL| JV , Tensile stress stimulates microtubule outgrowth in living cells. Journal of cell science. 2002 Jun 1; 115 (Pt 11). 2283-91

2000

Kaverina| Krylyshkina| Gimona| Beningo| Wang| Small I| O| M| K| YL| JV , Enforced polarisation and locomotion of fibroblasts lacking microtubules. Current biology : CB. 2000 Jun 15; 10 (12). 739-42

1999

Kaverina| Krylyshkina| Small I| O| JV , Microtubule targeting of substrate contacts promotes their relaxation and dissociation. The Journal of cell biology. 1999 Sep 6; 146 (5). 1033-44

1998

Kaverina| Rottner| Small I| K| JV , Targeting, capture, and stabilization of microtubules at early focal adhesions. The Journal of cell biology. 1998 Jul 13; 142 (1). 181-90