Iverson Lab

Background

Postdoc, Columbia University

Ph.D. Pharmacology, Vanderbilt University, 2019

B.S. Biology, Wittenberg University, 2014

B.A. Chemistry, Wittenberg University, 2014

Publications From the Lab

Development of Mutant M₃ Muscarinic Receptors Biased for G Protein Activation or Recruitment of β-Arrestins. Meister J, Wanka L, Perry-Hauser NA, Liu L, Iverson TM, Gurevich VV, Beck-Sickinger AG, Kruse AC, Wess J.Biochemistry. 2025 Jul 1;64(13):2727-2736. doi: 10.1021/acs.biochem.5c00036

Short Arrestin-3-Derived Peptides Activate JNK3 in Cells. Perry-Hauser NA, Kaoud TS, Stoy H, Zhan X, Chen Q, Dalby KN, Iverson TM, Gurevich VV, Gurevich EV.Int J Mol Sci. 2022 Aug 4;23(15):8679. doi: 10.3390/ijms23158679.

The Two Non-Visual Arrestins Engage ERK2 Differently. Perry-Hauser NA, Hopkins JB, Zhuo Y, Zheng C, Perez I, Schultz KM, Vishnivetskiy SA, Kaya AI, Sharma P, Dalby KN, Chung KY, Klug CS, Gurevich VV, Iverson TM.J Mol Biol. 2022 Apr 15;434(7):167465. doi: 10.1016/j.jmb.2022.167465. Epub 2022 Jan 22.

Phosphorylation barcode-dependent signal bias of the dopamine D1 receptor. Kaya AI, Perry NA, Gurevich VV, Iverson TM.Proc Natl Acad Sci U S A. 2020 Jun 23;117(25):14139-14149. doi: 10.1073/pnas.1918736117. Epub 2020 Jun 5.

Arrestin-3 interaction with maternal embryonic leucine-zipper kinase. Perry NA, Fialkowski KP, Kaoud TS, Kaya AI, Chen AL, Taliaferro JM, Gurevich VV, Dalby KN, Iverson TM.Cell Signal. 2019 Nov;63:109366. doi: 10.1016/j.cellsig.2019.109366. 

A Novel Class of Common Docking Domain Inhibitors That Prevent ERK2 Activation and Substrate Phosphorylation. Sammons RM, Perry NA, Li Y, Cho EJ, Piserchio A, Zamora-Olivares DP, Ghose R, Kaoud TS, Debevec G, Bartholomeusz C, Gurevich VV, Iverson TM, Giulianotti M, Houghten RA, Dalby KN.ACS Chem Biol. 2019 Jun 21;14(6):1183-1194. doi: 10.1021/acschembio.9b00093. Epub 2019 May 13.

Using in Vitro Pull-Down and In-Cell Overexpression Assays to Study Protein Interactions with Arrestin. Perry NA, Zhan X, Gurevich EV, Iverson TM, Gurevich VV.Methods Mol Biol. 2019;1957:107-120.

Arrestin-3 scaffolding of the JNK3 cascade suggests a mechanism for signal amplification. Perry NA, Kaoud TS, Ortega OO, Kaya AI, Marcus DJ, Pleinis JM, Berndt S, Chen Q, Zhan X, Dalby KN, Lopez CF, Iverson TM, Gurevich VV. (2018). Proc Natl Acad Sci U S A. 2018 Dec 27. pii: 201819230.

Structural basis of arrestin-3 activation and signaling. Chen Q , Perry NA , Vishnivetskiy SA , Berndt S , Gilbert NC , Zhuo Y , Singh PK , Tholen J , Ohi MD , Gurevich EV , Brautigam CA , Klug CS , Gurevich VV , Iverson TM ,  (2017). Nature communications. 2017 Nov 10; 8 (1). 1427

Differential manipulation of arrestin-3 binding to basal and agonist-activated G protein-coupled receptors. Prokop S. , Perry NA , Vishnivetskiy SA , Toth AD , Inoue A , Milligan G, Iverson TM , Hunyady L , Gurevich VV. (2017).  Cellular signalling. 2017 Aug ; 36 98-107

Peptide mini-scaffold facilitates JNK3 activation in cells. Zhan X, Stoy H, Kaoud TS, Perry NA, Chen Q, Perez A, Els-Heindl S, Slagis JV, Iverson TM, Beck-Sickinger AG, Gurevich EV, Dalby KN, Gurevich VV. (2016). Scientific Reports, 6, 21025. http://doi.org/10.1038/srep21025