Nathaniel C. Gilbert, Ph.D.

Background

BS, Louisiana State University

PhD, Louisiana State University

Postdoc, Vanderbilt University

Publications from the lab

Structural basis of arrestin-3 activation and signaling. Chen Q, Perry NA, Vishnivetskiy SA, Berndt S, Gilbert NC, Zhuo Y, Singh PK, Tholen J, Ohi MD, Gurevich EV, Brautigam CA, Klug CS, Gurevich VV, Iverson TM. Nat Commun. 2017 Nov 10;8(1):1427. doi: 10.1038/s41467-017-01218-8. PMID: 29127291 Free PMC article.

Past Publications

Conversion of human 5-lipoxygenase to a 15-lipoxygenase by a point mutation to mimic phosphorylation at Serine-663. Gilbert NC, Rui Z, Neau DB, Waight MT, Bartlett SG, Boeglin WE, Brash AR, Newcomer ME. FASEB J. 2012 Aug;26(8):3222-9. doi: 10.1096/fj.12-205286. Epub 2012 Apr 18. PMID: 22516296 Free PMC article.

Structure of a calcium-dependent 11R-lipoxygenase suggests a mechanism for Ca2+ regulation. Eek P, Järving R, Järving I, Gilbert NC, Newcomer ME, Samel N. J Biol Chem. 2012 Jun 22;287(26):22377-86. doi: 10.1074/jbc.M112.343285. Epub 2012 May 9. PMID: 22573333 Free PMC article.

The structure of human 5-lipoxygenase. Gilbert NC, Bartlett SG, Waight MT, Neau DB, Boeglin WE, Brash AR, Newcomer ME. Science. 2011 Jan 14;331(6014):217-9. doi: 10.1126/science.1197203. PMID: 21233389

Location, location, location: compartmentalization of early events in leukotriene biosynthesis. Newcomer ME, Gilbert NC. J Biol Chem. 2010 Aug 13;285(33):25109-14. doi: 10.1074/jbc.R110.125880. Epub 2010 May 27. PMID: 20507998

The 1.85 A structure of an 8R-lipoxygenase suggests a general model for lipoxygenase product specificity. Neau DB, Gilbert NC, Bartlett SG, Boeglin W, Brash AR, Newcomer ME. Biochemistry. 2009 Aug 25;48(33):7906-15. doi: 10.1021/bi900084m. PMID: 19594169 Free PMC article.

Changes in non-high-density lipoprotein cholesterol levels and triglyceride/high-density lipoprotein cholesterol ratios among patients randomized to aripiprazole versus olanzapine. Newcomer JW, Meyer JM, Baker RA, Eudicone JM, Pikalov A, Vester-Blokland E, McQuade RD, Crandall DT, Carson WH, Marcus RN, L’italien G. Schizophr Res. 2008 Dec;106(2-3):300-7. doi: 10.1016/j.schres.2008.09.002. Epub 2008 Oct 29. PMID: 18973991 Free PMC article.

A covalent linker allows for membrane targeting of an oxylipin biosynthetic complex. Gilbert NC, Niebuhr M, Tsuruta H, Bordelon T, Ridderbusch O, Dassey A, Brash AR, Bartlett SG, Newcomer ME. Biochemistry. 2008 Oct 7;47(40):10665-76. doi: 10.1021/bi800751p. Epub 2008 Sep 12. PMID: 18785758 Free PMC article.

Improving protein crystal quality by selective removal of a Ca(2+)-dependent membrane-insertion loop. Neau DB, Gilbert NC, Bartlett SG, Dassey A, Newcomer ME. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2007 Nov 1;63(Pt 11):972-5. doi: 10.1107/S1744309107050993. Epub 2007 Oct 24.