Maruf Sarwar, M.D.

Background

B.A. University of Rochester

M.D. University of Tennessee Health Sciences Center

Publications from the lab

Oxidative cyclizations in orthosomycin biosynthesis expand the known chemistry of an oxygenase superfamily.
McCulloch KM, McCranie EK, Smith JA, Sarwar M, Mathieu JL, Gitschlag BL, Du Y, Bachmann BO, Iverson TM. Proc Natl Acad Sci U S A. 2015 Sep 15;112(37):11547-52. doi: 10.1073/pnas.1500964112. Epub 2015 Aug 3. PMID: 26240321

A transient interaction between the phosphate binding loop and switch I contributes to the allosteric network between receptor and nucleotide in Gαi1.
Thaker TM, Sarwar M, Preininger AM, Hamm HE, Iverson TM. J Biol Chem. 2014 Apr 18;289(16):11331-11341. doi: 10.1074/jbc.M113.539064. Epub 2014 Mar 4. PMID: 24596087

Plasticity of the quinone-binding site of the complex II homolog quinol:fumarate reductase.
Singh PK, Sarwar M, Maklashina E, Kotlyar V, Rajagukguk S, Tomasiak TM, Cecchini G, Iverson TM. J Biol Chem. 2013 Aug 23;288(34):24293-301. doi: 10.1074/jbc.M113.487082. Epub 2013 Jul 8. PMID: 23836905

Geometric restraint drives on- and off-pathway catalysis by the Escherichia coli menaquinol:fumarate reductase.
Tomasiak TM, Archuleta TL, Andréll J, Luna-Chávez C, Davis TA, Sarwar M, Ham AJ, McDonald WH, Yankovskaya V, Stern HA, Johnston JN, Maklashina E, Cecchini G, Iverson TM. J Biol Chem. 2011 Jan 28;286(4):3047-56. doi: 10.1074/jbc.M110.192849. Epub 2010 Nov 23.