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Iverson Lab

Kathryn McCulloch, Ph.D.

Associate Professor (with Tenure), Chemistry and Biochemistry, California Polytechnic University, Pomona
Associate Chair, Chemistry and Biochemistry, California Polytechnic University, Pomona

Background

Ph.D. Cornell University, Chemistry and Chemical Biology, 2010
M.S. Cornell University, Chemistry and Chemical Biology, 2006
B.S. Ball State University, Chemistry, 2004

Publications from the lab

An alternative N-terminal fold of the intestine-specific annexin A13a induces dimerization and regulates membrane-binding. McCulloch KM, Yamakawa I, Shifrin DA Jr, McConnell RE, Foegeding NJ, Singh PK, Mao S, Tyska MJ, Iverson TM.J Biol Chem. 2019 Mar 8;294(10):3454-3463. doi: 10.1074/jbc.RA118.004571. Epub 2019 Jan 4.PMID: 30610115

The Structure of the Bifunctional Everninomicin Biosynthetic Enzyme EvdMO1 Suggests Independent Activity of the Fused Methyltransferase-Oxidase Domains. Starbird CA, Perry NA, Chen Q, Berndt S, Yamakawa I, Loukachevitch LV, Limbrick EM, Bachmann BO, Iverson TM, McCulloch KM .Biochemistry. 2018 Dec 18;57(50):6827-6837. doi: 10.1021/acs.biochem.8b00836. Epub 2018 Dec 7.

 

Past Publications

McCulloch, K.M., Mukherjee, T., Begley, T.P., and Ealick, S.E. (2010) Structure Determination and Characterization of the Vitamin B6 Degradative Enzyme 2-(Acetamidomethylene)succinate Hydrolase.  Biochemistry. 49(6): 1226-1235.

Mukherjee, T., McCulloch, K.M., Ealick, S.E., and Begley, T.P. (2010) Cofactor Catabolism – An Underexplored Frontier, in Cofactor Metabolism, in Comprehensive Natural Products Chemistry II (Mander, L. and Liu, H-W., Ed.) Elsevier Science, Oxford. Vol 7: 649-674.

McCulloch, K.M., Mukherjee, T., Begley, T.P., and Ealick, S.E. (2009) Structure of the PLP Degradative Enzyme 2-Methyl-3-hydroxypyridine-5-carboxylic Acid Oxygenase from Mesorhizobium loti MAFF303099 and Its Mechanistic Implications.  Biochemistry. 48(19): 4139-4149.

McCulloch, K.M., Kinsland, C., Begley, T.P., and Ealick, S.E. (2008) Structural Studies of Thiamin Monophosphate Kinase in Complex with Substrates and Products.  Biochem. 47, 3810-3821.

Mukherjee, T.*, McCulloch, K.M.*, Ealick, S.E., and Begley, T.P. (2007) Gene Identification and Structural Characterization of the Pyridoxal 5′-Phosphate Degradative Protein 3-Hydroxy-2-methylpyridine-4,5-dicarboxylate Decarboxylase from Mesorhizobium loti MAFF303099.  Biochem. 46, 13606-13615. * these authors contributed equally to this work.

Owegi, M.A., Pappas, D.L., Finch, M.W., Bilbo, S.A., Resendiz, C.A., Jacquemin, L.J., Warrier, A., Trombley, J.D., McCulloch, K.M., Margalef, K.L.M., Mertz, M.J., Storms, J.M., Damin, C.A., and Parra, K.J. (2006) Identification of a Domain in the Vo Subunit d that is Critical for Coupling of the Yeast Vacuolar Proton-translocating ATPase.  J. Biol. Chem. 281, 30001-30014.

Parra-Belky, K., McCulloch, K.M., Wick, N., Shircliff, R., Croft, N., Margalef, K., Brown, J., Crabill, T., Jankord, R., and Waldo, E. (2005) Immunoprecipitation and Characterization of Membrane Protein Complexes from Yeast.  Biochem. and Mol. Biol. Ed. 33, 289-292.