Ali I. Kaya, Ph.D.
Staff Scientist at NE-CAT, Advanced Photon Source, Argonne National Laboratory / Cornell University
Background
Research Assistant Professor, Department of Pharmacology. Vanderbilt University
Postdoc, Department of Pharmacology. Vanderbilt University
PhD, Biotechnology Institute, University of Ankara, Turkey
MSc, School of Medicine, Medical Biology Department, University of Ankara, Turkey
Publications from the lab
The Two Non-Visual Arrestins Engage ERK2 Differently. J Mol Biol. 2022 Apr 15;434(7):167465. doi: 10.1016/j.jmb.2022.167465. Epub 2022 Jan 22.PMID: 35077767
Phosphorylation barcode-dependent signal bias of the dopamine D1 receptor. Proc Natl Acad Sci U S A. 2020 Jun 23;117(25):14139-14149. doi: 10.1073/pnas.1918736117. Epub 2020 Jun 5.PMID: 32503917
Arrestin-3 interaction with maternal embryonic leucine-zipper kinase. Cell Signal. 2019 Nov;63:109366. doi: 10.1016/j.cellsig.2019.109366. Epub 2019 Jul 25.PMID: 31352007
Kaya AI, Lokits AD, Gilbert JA, Iverson TM, Meiler J, and Hamm HE. A conserved hydrophobic core in Gαi1 regulates G protein activation and release from activated receptor. J. Biol. Chem. 2016, 291 (37): 19674-86.
Kaya AI, Iverson TM and Hamm HE. Functional stability of rhodopsin in a bicelle system: evaluating G protein activation by rhodopsin in bicelles. Methods Mol Biol. 2015, 1271:67-76.
Kaya AI, Lokits AD, Gilbert JA, Iverson TM, Meiler J, Hamm HE. A Conserved Phenylalanine as a Relay between the α5 Helix and the GDP Binding Region of Heterotrimeric Gi Protein α Subunit. J. Biol. Chem. 2014, 289(35): 24475-24487.
Prior Publications
Alexander NS, Preininger AM, Kaya AI, Stein RA, Hamm HE, Meiler J. Energetic analysis of the R*-G complex links the α5 helix to GDP release and domain opening. Nat. Struct. Mol. Biol. 2014, 21(1): 56-63.
Hamm HE, Kaya AI, Gilbert JA 3rd, Preininger AM. Linking receptor activation to changes in Sw I and II of Gα proteins. J. Struct. Biol. 2013, 184(11): 63-74.
Preininger AM*, Kaya AI*, Gilbert JA 3rd, Busenlehner LS, Armstrong RN, Hamm HE. Myristoylation exerts direct and allosteric effects on Gα conformation and dynamics in solution. Biochemistry. 2012, 51(9): 1911-24. *Contributed equally.
Kaya AI, Onaran HO, Ozcan G, Ambrosio C, Costa T, Balh S, Ugur O. Cell Contact-Dependent Functional Selectivity of β2-Adrenergic Receptor Ligands in Stimulating cAMP Accumulation and Extracellular Signal-Regulated Kinase (ERK) Phosphorylation. J. Biol. Chem. 2012, 287: 6362-74.
Thaker TM, Kaya AI, Preininger AM, Hamm HE, Iverson TM. Allosteric mechanisms of G protein-Coupled Receptor signaling: a structural perspective. Methods Mol. Biol. 2012,796:133-74.
Kaya AI, Ugur O, Altuntas O, Sayar K, Onaran HO. Long and short distance movements of β(2)-adrenoceptor in cell membrane assessed by photoconvertible fluorescent protein dendra2-β(2)-adrenoceptor fusion. Biochim. Biophys. Acta. 2011, 1813(8):1511-24.
Van Eps N, Preininger AM, Alexander N, Kaya AI, Meier S, Meiler J, Hamm HE, Hubbell WL. Interaction of a G protein with an activated receptor opens the interdomain interface in the alpha subunit. PNAS. 2011, 108(23);9420-9424.
Kaya AI, Thaker TM, Preininger AM, Iverson TM, Hamm HE. Coupling Efficiency of Rhodopsin and Transducin in Bicelles. Biochemistry. 2011, 15(50); 3193-3203.
Oner SS, Kaya AI, Onaran HO, Ozcan G, Ugur O. β2-Adrenoceptor, Gs and adenylate cyclase coupling in purified detergent-resistant, low-density membrane fractions. Eur J Pharmacol. 2010, 630: 42-52.
Kaya AI, Ugur O, Oner SS, Bastepe M, Onaran HO. Coupling of β2-adrenoceptors to XLas and Gαs: A new insight into ligand-induced G protein activation. J. Pharmacol. Exp. Ther. 2009, 329: 350-359.
Elcioglu NH, Akin B, Toker E, Elcioglu M, Kaya AI, Tuncali T, Wollnik B, Hornby S, Akarsu NA. Colobomatous macrophthalmia with microcornea syndrome maps to the 2p23-p16 region. Am. J. Hum. Gen. 2007, 143(12); 1308-1312.