Qiuyan Chen, Ph.D.

Assistant Professor, Indiana University

Background

B.S. Biotechnology, Tongji University, 2010

Ph.D. Pharmacology, Vanderbilt University 2015

Publications from the lab

Short Arrestin-3-Derived Peptides Activate JNK3 in Cells. Perry-Hauser NA, Kaoud TS, Stoy H, Zhan X, Chen Q, Dalby KN, Iverson TM, Gurevich VV, Gurevich EV.Int J Mol Sci. 2022 Aug 4;23(15):8679. doi: 10.3390/ijms23158679.PMID: 35955810

An Eight Amino Acid Segment Controls Oligomerization and Preferred Conformation of the two Non-visual Arrestins. Chen Q, Zhuo Y, Sharma P, Perez I, Francis DJ, Chakravarthy S, Vishnivetskiy SA, Berndt S, Hanson SM, Zhan X, Brooks EK, Altenbach C, Hubbell WL, Klug CS, Iverson TM, Gurevich VV.J Mol Biol. 2021 Feb 19;433(4):166790. doi: 10.1016/j.jmb.2020.166790. Epub 2020 Dec 31.PMID: 33387531

Arrestin-3 scaffolding of the JNK3 cascade suggests a mechanism for signal amplification. Perry NA, Kaoud TS, Ortega OO, Kaya AI, Marcus DJ, Pleinis JM, Berndt S, Chen Q, Zhan X, Dalby KN, Lopez CF, Iverson TM, Gurevich VV.Proc Natl Acad Sci U S A. 2019 Jan 15;116(3):810-815. doi: 10.1073/pnas.1819230116. Epub 2018 Dec 27.PMID: 30591558

Structural Basis of Arrestin-Dependent Signal Transduction. Chen Q, Iverson TM, Gurevich VV.Trends Biochem Sci. 2018 Jun;43(6):412-423. doi: 10.1016/j.tibs.2018.03.005. Epub 2018 Apr 7.PMID: 29636212 Review.

Structural basis of arrestin-3 activation and signaling. Chen Q, Perry NA, Vishnivetskiy SA, Berndt S, Gilbert NC, Zhuo Y, Singh PK, Tholen J, Ohi MD, Gurevich EV, Brautigam CA, Klug CS, Gurevich VV, Iverson TM.Nat Commun. 2017 Nov 10;8(1):1427. doi: 10.1038/s41467-017-01218-8.PMID: 29127291

Using two-site binding models to analyze microscale thermophoresis data. Tso SC, Chen Q, Vishnivetskiy SA, Gurevich VV, Iverson TM, Brautigam CA.Anal Biochem. 2018 Jan 1;540-541:64-75. doi: 10.1016/j.ab.2017.10.013. Epub 2017 Oct 18.PMID: 29054528

Peptide mini-scaffold facilitates JNK3 activation in cells. Zhan X, Stoy H, Kaoud TS, Perry NA, Chen Q, Perez A, Els-Heindl S, Slagis JV, Iverson TM, Beck-Sickinger AG, Gurevich EV, Dalby KN, Gurevich VV.Sci Rep. 2016 Feb 12;6:21025. doi: 10.1038/srep21025.PMID: 26868142

The rhodopsin-arrestin-1 interaction in bicelles. Chen Q, Vishnivetskiy SA, Zhuang T, Cho MK, Thaker TM, Sanders CR, Gurevich VV, Iverson TM.Methods Mol Biol. 2015;1271:77-95. doi: 10.1007/978-1-4939-2330-4_6.PMID: 25697518

Arrestin expression in E. coli and purification. Vishnivetskiy SA, Zhan X, Chen Q, Iverson TM, Gurevich VV.Curr Protoc Pharmacol. 2014 Dec 1;67:2.11.1-2.11.19. doi: 10.1002/0471141755.ph0211s67.PMID: 25446290

Involvement of distinct arrestin-1 elements in binding to different functional forms of rhodopsin. Zhuang T, Chen Q, Cho MK, Vishnivetskiy SA, Iverson TM, Gurevich VV, Sanders CR.Proc Natl Acad Sci U S A. 2013 Jan 15;110(3):942-7. doi: 10.1073/pnas.1215176110. Epub 2012 Dec 31.