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The Hiebert Laboratory

The Hiebert Laboratory Publications

2023

Layden HM , Jones AL , Ellis JD , Hiebert SW , A dual indexed approach to small RNA sequencing library preparation for PRO-seq Research Square. 2023 Jun 30;
Bomber ML , Wang J , Liu Q , Barnett KR , Layden HM , Hodges E , Stengel KR , Hiebert SW , Human SMARCA5 is continuously required to maintain nucleosome spacing Molecular Cell. 2023 Feb 16;

2022

Zhang S , Wang J , Liu Q , McDonald WH , Bomber ML , Layden HM , Ellis JD , Borinstein SC , Hiebert SW , Stengel KR , PAX3-FOXO1 coordinates enhancer architecture, eRNA transcription, and RNA polymerase pause release at select gene targets Molecular Cell. 2022 Dec 1;
Brown RE , Jacobse J , Anant SA , Blunt KM , Chen B , Vega PN , Jones CT , Pilat JM , Revetta F , Gorby AH , Stengel KR , Choski YA , Palin K , Piazuelo MB , Washington MK , Lau KS , Goettel JA , Williams CS , MTG16 regulates colonic epithelial differentiation, colitis, and tumorigenesis by repressing E protein transcription factors JCI Insight. 2022 May 23;

2021

Ramsey HE , Stengel KR , Pino JC , Johnston G , Childress M , Gorska AE , Arrate PM , Fuller L , Villaume M , Fischer MA , Ferrell PB , Roe CE , Zhou J , Lubbock ALR , Stubbs M , Zinkel S , Irish JM , Lopez CF , Hiebert SW , Savona MR , Selective Inhibition of JAK1 Primes STAT5-Driven Human Leukemia Cells for ATRA-Induced Differentiation Targeted Oncology. 2021 Sep 16;
Layden HM , Eleuteri NA , Hiebert SW , Stengel KR , A protocol for rapid degradation of endogenous transcription factors in mammalian cells and identification of direct regulatory targets Star Protocols. 2021 May 19;
Stengel KR , Ellis JD , Spielman CL , Bomber ML , Layden SW , Definition of a small core transcriptional circuit regulated by AML1-ETO Molecular Cell. 2021 Dec 30;

2020

Ramsey HE , Greenwood D , Zhang S , Childress M , Arrate MP , Gorska AE , Fuller L , Zhao Y , Stengel KR , Fischer MA , Stubbs MC , Liu PC , Boyd K , Rathmell JC , Hiebert SW , Savona MR , BET Inhibition Enhances the Antileukemic Activity of Low-dose Venetoclax in Acute Myeloid Leukemia Clinical Cancer Research. 2020 Nov 4;
Johnston G. , Ramsey H. , Liu Q. , Wang J. , Stengel K. R. , Sampathi S. , Arharya P. , Arrate M. , Stubbs M. C. , Burn T. , Savona M. R. , Hiebert S. W. , Nascent transcript and single-cell RNA-seq analysis defines the mechanism of action of the LSD1 inhibitor INCB059872 in myeloid leukemia Gene. 2020 May 15;

2019

Stengel K.R. , Bhaskara S. , Wang J. , Liu Q. , Ellis J.D. , Sampathi S. , Hiebert S.W. , Histone deacetylase 3 controls a transcriptional network required for B cell maturation Nucleic Acids Research. 2019 Oct 5; 47 (20). 10612-10627
Sampathi S , Acharya P , Zhao Y , Wang J , Stengel KR , Liu Q , Savona MR , Hiebert SW , The CDK7 inhibitor THZ1 alters RNA polymerase dynamics at the 5′ and 3′ ends of genes Nucleic acids research. 2019 May 7; 47 (8). 3921-3936
Short SP , Barrett CW , Stengel KR , Revetta FL , Choksi YA , Coburn LA , Lintel MK , McDonough EM , Washington MK , Wilson KT , Prokhortchouk E , Chen X , Hiebert SW , Reynolds AB , Williams CS , Kaiso is required for MTG16-dependent effects on colitis-associated carcinoma Oncogene. 2019 Mar 11; 38 (25). 5091-5106
Aho E.R. , Wang J. , Gogliotti R.D. , Howard G.C. , Phan J. , Acharya P. , Macdonald J.D. , Cheng K. , Lorey L. , Lu B. , Wenzel S. , Foshage A.M. , Alvarado J. , Wang F. , Shaw J.G. , Zhao B. , Weissmiller A.M. , Thomas L.R. , Vakoc C.R. , Hall M.D. , Hiebert S.W. , Liu Q. , Stauffer S.R. , Fesik S.W. , Tansey W.P. , Displacement of WDR5 from Chromatin by a WIN Site Inhibitor with Picomolar Affinity. Cell Reports. 2019 Mar 12; 26 (11). 2916-2928

2018

Wang J , Zhao Y , Zhou X , Hiebert SW , Liu Q , Shyr Y , Nascent RNA sequencing analysis provides insights into enhancer-mediated gene regulation BMC genomics. 2018 Aug 23; 19 (1). 633
Zhang S , Zhao Y , Heaster TM , Fischer MA , Stengel KR , Zhou X , Ramsey H , Zhou MM , Savona MR , Skala MC , Hiebert SW , BET inhibitors reduce cell size and induce reversible cell cycle arrest in AML Journal of cellular biochemistry. 2018 Nov 11;

2017

Liu Q , Wang J , Zhao Y , Li CI , Stengel KR , Acharya P , Johnston G , Hiebert SW , Shyr Y , Identification of active miRNA promoters from nuclear run-on RNA sequencing Nucleic acids research. 2017 Jul 27; 45 (13). e121
Heaster TM , Walsh AJ , Zhao Y , Hiebert SW , Skala MC , Autofluorescence imaging identifies tumor cell-cycle status on a single-cell level Journal of biophotonics. 2017 May 09; 11 (1).
Ferrari A , Longo R , Fiorino E , Silva R , Mitro N , Cermenati G , Gilardi F , Desvergne B , Andolfo A , Magagnotti C , Caruso D , Fabiani E , Hiebert SW , Crestani M , HDAC3 is a molecular brake of the metabolic switch supporting white adipose tissue browning Nature communications. 2017 Jul 21; 8 (1). 93
Stengel KR , Barnett KR , Wang J , Liu Q , Hodges E , Hiebert SW , Bhaskara S , Deacetylase activity of histone deacetylase 3 is required for productive recombination and B-cell development Proceedings of the National Academy of Sciences of the United States of America. 2017 Jul 24; 114 (32). 8608-8613
McDonough EM , Barrett CW , Parang B , Mittal MK , Smith JJ , Bradley AM , Choksi YA , Coburn LA , Short SP , Thompson JJ , Zhang B , Poindexter SV , Fischer MA , Chen X , Li J , Revetta FL , Naik R , Washington MK , Rosen MJ , Hiebert SW , Wilson KT , Williams CS , MTG16 is a tumor suppressor in colitis-associated carcinoma JCI insight. 2017 Aug 17; 2 (16).

2016

Chan E , Arlinghaus LR , Cardin DB , Goff L , Berlin JD , Parikh A , Abramson RG , Yankeelov TE , Hiebert S , Merchant N , Bhaskara S , Chakravarthy AB , Phase I trial of vorinostat added to chemoradiation with capecitabine in pancreatic cancer Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology. 2016 Apr 19; 119 (2). 312-8
Hargrove TY , Friggeri L , Wawrzak Z , Sivakumaran S , Yazlovitskaya EM , Hiebert SW , Guengerich FP , Waterman MR , Lepesheva GI , Human sterol 14α-demethylase as a target for anticancer chemotherapy: towards structure-aided drug design Journal of lipid research. 2016 Jun 16; 57 (8). 1552-63
Zhao Y , Liu Q , Acharya P , Stengel KR , Sheng Q , Zhou X , Kwak H , Fischer MA , Bradner JE , Strickland SA , Mohan SR , Savona MR , Venters BJ , Zhou MM , Lis JT , Hiebert SW , High-Resolution Mapping of RNA Polymerases Identifies Mechanisms of Sensitivity and Resistance to BET Inhibitors in t(8;21) AML Cell reports. 2016 Aug 04; 16 (7). 2003-16
Cho SH , Raybuck AL , Stengel K , Wei M , Beck TC , Volanakis E , Thomas JW , Hiebert S , Haase VH , Boothby MR , Germinal centre hypoxia and regulation of antibody qualities by a hypoxia response system Nature. 2016 Aug 08; 537 (7619). 234-238
Jiang Y , Ortega-Molina A , Geng H , Ying HY , Hatzi K , Parsa S , McNally D , Wang L , Doane AS , Agirre X , Teater M , Meydan C , Li Z , Poloway D , Wang S , Ennishi D , Scott DW , Stengel KR , Kranz JE , Holson E , Sharma S , Young JW , Chu CS , Roeder RG , Shaknovich R , Hiebert SW , Gascoyne RD , Tam W , Elemento O , Wendel HG , Melnick AM , CREBBP Inactivation Promotes the Development of HDAC3-Dependent Lymphomas Cancer discovery. 2016 Oct 12; 7 (1). 38-53

2015

Poindexter SV , Reddy VK , Mittal MK , Williams AM , Washington MK , Harris E , Mah A , Hiebert SW , Singh K , Chaturvedi R , Wilson KT , Lund PK , Williams CS , Transcriptional corepressor MTG16 regulates small intestinal crypt proliferation and crypt regeneration after radiation-induced injury American journal of physiology. Gastrointestinal and liver physiology. 2015 Jan 08; 308 (6). G562-71
Dutta P , Sager HB , Stengel KR , Naxerova K , Courties G , Saez B , Silberstein L , Heidt T , Sebas M , Sun Y , Wojtkiewicz G , Feruglio PF , King K , Baker JN , van der Laan AM , Borodovsky A , Fitzgerald K , Hulsmans M , Hoyer F , Iwamoto Y , Vinegoni C , Brown D , Di Carli M , Libby P , Hiebert SW , Scadden DT , Swirski FK , Weissleder R , Nahrendorf M , Myocardial Infarction Activates CCR2(+) Hematopoietic Stem and Progenitor Cells Cell stem cell. 2015 May 7; 16 (5). 477-87
Hsu FC , Belmonte PJ , Constans MM , Chen MW , McWilliams DC , Hiebert SW , Shapiro VS , Histone Deacetylase 3 Is Required for T Cell Maturation Journal of immunology (Baltimore, Md. : 1950). 2015 Jul 10; 195 (4). 1578-90
Wang L , Liu Y , Han R , Beier UH , Bhatti TR , Akimova T , Greene MI , Hiebert SW , Hancock WW , FOXP3⁺ regulatory T cell development and function require histone/protein deacetylase 3 The Journal of clinical investigation. 2015 Aug 03; 125 (8). 3304
Stengel KR , Zhao Y , Klus NJ , Kaiser JF , Gordy LE , Joyce S , Hiebert SW , Summers AR , Histone Deacetylase 3 Is Required for Efficient T Cell Development Molecular and cellular biology. 2015 Aug 31; 35 (22). 3854-65
Adams CM , Hiebert SW , Eischen CM , Myc Induces miRNA-Mediated Apoptosis in Response to HDAC Inhibition in Hematologic Malignancies Cancer research. 2015 Dec 16; 76 (3). 736-48

2014

Stengel KR , Hiebert SW , Class I HDACs Affect DNA Replication, Repair, and Chromatin Structure: Implications for Cancer Therapy Antioxidants & redox signaling. 2014 Jun 26; 23 (1). 51-65
Ghosh HS , Ceribelli M , Matos I , Lazarovici A , Bussemaker HJ , Lasorella A , Hiebert SW , Liu K , Staudt LM , Reizis B , ETO family protein Mtg16 regulates the balance of dendritic cell subsets by repressing Id2 The Journal of experimental medicine. 2014 Jun 30; 211 (8). 1623-35
Parang B , Rosenblatt D , Williams AD , Washington MK , Revetta F , Short SP , Reddy VK , Hunt A , Shroyer NF , Engel ME , Hiebert SW , Williams CS , The transcriptional corepressor MTGR1 regulates intestinal secretory lineage allocation FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2014 Nov 14; 29 (3). 786-95

2013

Yan L , Womack B , Wotton D , Guo Y , Shyr Y , Davé U , Li C , Hiebert S , Brandt S , Hamid R , Tgif1 regulates quiescence and self-renewal of hematopoietic stem cells Molecular and cellular biology. 2013 Oct 07; 33 (24). 4824-33
Summers AR , Fischer MA , Stengel KR , Zhao Y , Kaiser JF , Wells CE , Hunt A , Bhaskara S , Luzwick JW , Sampathi S , Chen X , Thompson MA , Cortez D , Hiebert SW , HDAC3 is essential for DNA replication in hematopoietic progenitor cells. The Journal of clinical investigation. 2013 Jul 1; 123 (7). 3112-23
Hatzi K , Jiang Y , Huang C , Garrett-Bakelman F , Gearhart MD , Giannopoulou EG , Zumbo P , Kirouac K , Bhaskara S , Polo JM , Kormaksson M , MacKerell AD , Xue F , Mason CE , Hiebert SW , Prive GG , Cerchietti L , Bardwell VJ , Elemento O , Melnick A , A hybrid mechanism of action for BCL6 in B cells defined by formation of functionally distinct compl… Cell reports. 2013 Aug 15; 4 (3). 578-88
Wells CE , Bhaskara S , Stengel KR , Zhao Y , Sirbu B , Chagot B , Cortez D , Khabele D , Chazin WJ , Cooper A , Jacques V , Rusche J , Eischen CM , McGirt LY , Hiebert SW , Inhibition of histone deacetylase 3 causes replication stress in cutaneous T cell lymphoma. PloS one. 2013 ; 8 (7). e68915
Ziesché E , Kettner-Buhrow D , Weber A , Wittwer T , Jurida L , Soelch J , Müller H , Newel D , Kronich P , Schneider H , Dittrich-Breiholz O , Bhaskara S , Hiebert SW , Hottiger MO , Li H , Burstein E , Schmitz ML , Kracht M , The coactivator role of histone deacetylase 3 in IL-1-signaling involves deacetylation of p65 NF-κB… Nucleic acids research. 2013 Jan 7; 41 (1). 90-109
Williams CS , Bradley AM , Chaturvedi R , Singh K , Piazuelo MB , Chen X , McDonough EM , Schwartz DA , Brown CT , Allaman MM , Coburn LA , Horst SN , Beaulieu DB , Choksi YA , Washington MK , Williams AD , Fisher MA , Zinkel SS , Peek RM , Wilson KT , Hiebert SW , MTG16 contributes to colonic epithelial integrity in experimental colitis. Gut. 2013 Oct ; 62 (10). 1446-55

2012

Barrett CW , Smith JJ , Lu LC , Markham N , Stengel KR , Short SP , Zhang B , Hunt AA , Fingleton BM , Carnahan RH , Engel ME , Chen X , Beauchamp RD , Wilson KT , Hiebert SW , Reynolds AB , Williams CS , Kaiso directs the transcriptional corepressor MTG16 to the Kaiso binding site in target promoters. PloS one. 2012 ; 7 (12). e51205
Fischer MA , Moreno-Miralles I , Hunt A , Chyla BJ , Hiebert SW , Myeloid translocation gene 16 is required for maintenance of haematopoietic stem cell quiescence. The EMBO journal. 2012 Mar 21; 31 (6). 1494-505

2011

Hunt A , Fischer M , Engel ME , Hiebert SW , Mtg16/Eto2 contributes to murine T-cell development. Molecular and cellular biology. 2011 Jul ; 31 (13). 2544-51
Bhaskara S , Hiebert SW , Role for histone deacetylase 3 in maintenance of genome stability. Cell cycle (Georgetown, Tex.). 2011 Mar 1; 10 (5). 727-8
Barrett CW , Fingleton B , Williams A , Ning W , Fischer MA , Washington MK , Chaturvedi R , Wilson KT , Hiebert SW , Williams CS , MTGR1 is required for tumorigenesis in the murine AOM/DSS colitis-associated carcinoma model. Cancer research. 2011 Feb 15; 71 (4). 1302-12
Zheng S , Tansey WP , Hiebert SW , Zhao Z , Integrative network analysis identifies key genes and pathways in the progression of hepatitis C vir… BMC medical genomics. 2011 ; 4 62
Wilson AJ , Holson E , Wagner F , Zhang YL , Fass DM , Haggarty SJ , Bhaskara S , Hiebert SW , Schreiber SL , Khabele D , The DNA damage mark pH2AX differentiates the cytotoxic effects of small molecule HDAC inhibitors in … Cancer biology & therapy. 2011 Sep 15; 12 (6). 484-93
Sirbu BM , Couch FB , Feigerle JT , Bhaskara S , Hiebert SW , Cortez D , Analysis of protein dynamics at active, stalled, and collapsed replication forks. Genes & development. 2011 Jun 15; 25 (12). 1320-7

2010

Bhaskara S , Knutson SK , Jiang G , Chandrasekharan MB , Wilson AJ , Zheng S , Yenamandra A , Locke K , Yuan JL , Bonine-Summers AR , Wells CE , Kaiser JF , Washington MK , Zhao Z , Wagner FF , Sun ZW , Xia F , Holson EB , Khabele D , Hiebert SW , Hdac3 is essential for the maintenance of chromatin structure and genome stability. Cancer cell. 2010 Nov 16; 18 (5). 436-47
Razidlo DF , Whitney TJ , Casper ME , McGee-Lawrence ME , Stensgard BA , Li X , Secreto FJ , Knutson SK , Hiebert SW , Westendorf JJ , Histone deacetylase 3 depletion in osteo/chondroprogenitor cells decreases bone density and increase… PloS one. 2010 ; 5 (7). e11492
Huang F , Chandrasekharan MB , Chen YC , Bhaskara S , Hiebert SW , Sun ZW , The JmjN domain of Jhd2 is important for its protein stability, and the plant homeodomain (PHD) fing… The Journal of biological chemistry. 2010 Aug 6; 285 (32). 24548-61
Engel ME , Hiebert SW , The enemy within: dormant retroviruses awaken. Nature medicine. 2010 May ; 16 (5). 517-8
Compton LA , Hiebert SW , Anticancer therapy SMRT-ens up: targeting the BCL6-SMRT interaction in B cell lymphoma. Cancer cell. 2010 Apr 13; 17 (4). 315-6
Engel ME , Nguyen HN , Mariotti J , Hunt A , Hiebert SW , Myeloid translocation gene 16 (MTG16) interacts with Notch transcription complex components to integ… Molecular and cellular biology. 2010 Apr ; 30 (7). 1852-63
Engel ME , Hiebert SW , Proleukemic RUNX1 and CBFbeta mutations in the pathogenesis of acute leukemia. Cancer treatment and research. 2010 ; 145 127-47

2009

Cai Y , Xu Z , Xie J , Ham AJ , Koury MJ , Hiebert SW , Brandt SJ , Eto2/MTG16 and MTGR1 are heteromeric corepressors of the TAL1/SCL transcription factor in murine ery… Biochemical and biophysical research communications. 2009 Dec 11; 390 (2). 295-301
Yan M , Ahn EY , Hiebert SW , Zhang DE , RUNX1/AML1 DNA-binding domain and ETO/MTG8 NHR2-dimerization domain are critical to AML1-ETO9a leuke… Blood. 2009 Jan 22; 113 (4). 883-6

2008

Chyla BJ , Moreno-Miralles I , Steapleton MA , Thompson MA , Bhaskara S , Engel M , Hiebert SW , Deletion of Mtg16, a target of t(16;21), alters hematopoietic progenitor cell proliferation and line… Molecular and cellular biology. 2008 Oct ; 28 (20). 6234-47
Hanson CA , Wood LD , Hiebert SW , Cellular stress triggers TEL nuclear export via two genetically separable pathways. Journal of cellular biochemistry. 2008 May 15; 104 (2). 488-98
Farmer TE , Williams CS , Washington MK , Hiebert SW , Inactivation of the p19(ARF) tumor suppressor affects intestinal epithelial cell proliferation and i… Journal of cellular biochemistry. 2008 Aug 15; 104 (6). 2228-40
Bhaskara S , Chyla BJ , Amann JM , Knutson SK , Cortez D , Sun ZW , Hiebert SW , Deletion of histone deacetylase 3 reveals critical roles in S phase progression and DNA damage contr… Molecular cell. 2008 Apr 11; 30 (1). 61-72
Knutson SK , Chyla BJ , Amann JM , Bhaskara S , Huppert SS , Hiebert SW , Liver-specific deletion of histone deacetylase 3 disrupts metabolic transcriptional networks. The EMBO journal. 2008 Apr 9; 27 (7). 1017-28
Moore AC , Amann JM , Williams CS , Tahinci E , Farmer TE , Martinez JA , Yang G , Luce KS , Lee E , Hiebert SW , Myeloid translocation gene family members associate with T-cell factors (TCFs) and influence TCF-dep… Molecular and cellular biology. 2008 Feb ; 28 (3). 977-87

2007

Yang G , Thompson MA , Brandt SJ , Hiebert SW , Histone deacetylase inhibitors induce the degradation of the t(8;21) fusion oncoprotein. Oncogene. 2007 Jan 4; 26 (1). 91-101

2006

Reed-Inderbitzin E , Moreno-Miralles I , Vanden-Eynden SK , Xie J , Lutterbach B , Durst-Goodwin KL , Luce KS , Irvin BJ , Cleary ML , Brandt SJ , Hiebert SW , RUNX1 associates with histone deacetylases and SUV39H1 to repress transcription. Oncogene. 2006 Sep 21; 25 (42). 5777-86
Martinez JA , Williams CS , Amann JM , Ellis TC , Moreno-Miralles I , Washington MK , Gregoli P , Hiebert SW , Deletion of Mtgr1 sensitizes the colonic epithelium to dextran sodium sulfate-induced colitis. Gastroenterology. 2006 Aug ; 131 (2). 579-88

2005

Yang G , Khalaf W , van de Locht L , Jansen JH , Gao M , Thompson MA , van der Reijden BA , Gutmann DH , Delwel R , Clapp DW , Hiebert SW , Transcriptional repression of the Neurofibromatosis-1 tumor suppressor by the t(8;21) fusion protein… Molecular and cellular biology. 2005 Jul ; 25 (14). 5869-79
Ice RJ , Wildonger J , Mann RS , Hiebert SW , Comment on “Nervy links protein kinase A to plexin-mediated semaphorin repulsion”. Science (New York, N.Y.). 2005 Jul 22; 309 (5734). 558; author reply 558
Amann JM , Chyla BJ , Ellis TC , Martinez A , Moore AC , Franklin JL , McGhee L , Meyers S , Ohm JE , Luce KS , Ouelette AJ , Washington MK , Thompson MA , King D , Gautam S , Coffey RJ , Whitehead RH , Hiebert SW , Mtgr1 is a transcriptional corepressor that is required for maintenance of the secretory cell lineag… Molecular and cellular biology. 2005 Nov ; 25 (21). 9576-85

2004

Müller-Tidow C , Steffen B , Cauvet T , Tickenbrock L , Ji P , Diederichs S , Sargin B , Köhler G , Stelljes M , Puccetti E , Ruthardt M , deVos S , Hiebert SW , Koeffler HP , Berdel WE , Serve H , Translocation products in acute myeloid leukemia activate the Wnt signaling pathway in hematopoietic… Molecular and cellular biology. 2004 Apr ; 24 (7). 2890-904
Irvin BJ , Hiebert SW , AML-1 steps up to the platelets. Nature medicine. 2004 Mar ; 10 (3). 238-9

2003

Wood LD , Irvin BJ , Nucifora G , Luce KS , Hiebert SW , Small ubiquitin-like modifier conjugation regulates nuclear export of TEL, a putative tumor suppress… Proceedings of the National Academy of Sciences of the United States of America. 2003 Mar 18; 100 (6). 3257-62
Irvin BJ , Wood LD , Wang L , Fenrick R , Sansam CG , Packham G , Kinch M , Yang E , Hiebert SW , TEL, a putative tumor suppressor, induces apoptosis and represses transcription of Bcl-XL. The Journal of biological chemistry. 2003 Nov 21; 278 (47). 46378-86

2002

Linggi B , Müller-Tidow C , van de Locht L , Hu M , Nip J , Serve H , Berdel WE , van der Reijden B , Quelle DE , Rowley JD , Cleveland J , Jansen JH , Pandolfi PP , Hiebert SW , The t(8;21) fusion protein, AML1 ETO, specifically represses the transcription of the p14(ARF) tumor… Nature medicine. 2002 Jul ; 8 (7). 743-50

2001

Amann JM , Nip J , Strom DK , Lutterbach B , Harada H , Lenny N , Downing JR , Meyers S , Hiebert SW , ETO, a target of t(8;21) in acute leukemia, makes distinct contacts with multiple histone deacetylas… Molecular and cellular biology. 2001 Oct ; 21 (19). 6470-83

2000

Strom DK , Nip J , Westendorf JJ , Linggi B , Lutterbach B , Downing JR , Lenny N , Hiebert SW , Expression of the AML-1 oncogene shortens the G(1) phase of the cell cycle. The Journal of biological chemistry. 2000 Feb 4; 275 (5). 3438-45
Melnick A , Carlile GW , McConnell MJ , Polinger A , Hiebert SW , Licht JD , AML-1/ETO fusion protein is a dominant negative inhibitor of transcriptional repression by the promy… Blood. 2000 Dec 1; 96 (12). 3939-47
Lutterbach B , Westendorf JJ , Linggi B , Isaac S , Seto E , Hiebert SW , A mechanism of repression by acute myeloid leukemia-1, the target of multiple chromosomal translocat… The Journal of biological chemistry. 2000 Jan 7; 275 (1). 651-6
Fenrick R , Wang L , Nip J , Amann JM , Rooney RJ , Walker-Daniels J , Crawford HC , Hulboy DL , Kinch MS , Matrisian LM , Hiebert SW , TEL, a putative tumor suppressor, modulates cell growth and cell morphology of ras-transformed cells… Molecular and cellular biology. 2000 Aug ; 20 (16). 5828-39

1999

Lutterbach B , Hou Y , Durst KL , Hiebert SW , The inv(16) encodes an acute myeloid leukemia 1 transcriptional corepressor. Proceedings of the National Academy of Sciences of the United States of America. 1999 Oct 26; 96 (22). 12822-7
Fenrick R , Amann JM , Lutterbach B , Wang L , Westendorf JJ , Downing JR , Hiebert SW , Both TEL and AML-1 contribute repression domains to the t(12;21) fusion protein. Molecular and cellular biology. 1999 Oct ; 19 (10). 6566-74

1998

Westendorf JJ , Yamamoto CM , Lenny N , Downing JR , Selsted ME , Hiebert SW , The t(8;21) fusion product, AML-1-ETO, associates with C/EBP-alpha, inhibits C/EBP-alpha-dependent t… Molecular and cellular biology. 1998 Jan ; 18 (1). 322-33

1996

Okuda T , van Deursen J , Hiebert SW , Grosveld G , Downing JR , AML1, the target of multiple chromosomal translocations in human leukemia, is essential for normal f… Cell. 1996 Jan 26; 84 (2). 321-30
Hiebert SW , Sun W , Davis JN , Golub T , Shurtleff S , Buijs A , Downing JR , Grosveld G , Roussell MF , Gilliland DG , Lenny N , Meyers S , The t(12;21) translocation converts AML-1B from an activator to a repressor of transcription. Molecular and cellular biology. 1996 Apr ; 16 (4). 1349-55

1995

Meyers S , Lenny N , Hiebert SW , The t(8;21) fusion protein interferes with AML-1B-dependent transcriptional activation. Molecular and cellular biology. 1995 Apr ; 15 (4). 1974-82

1993

Meyers S , Downing JR , Hiebert SW , Identification of AML-1 and the (8;21) translocation protein (AML-1/ETO) as sequence-specific DNA-bi… Molecular and cellular biology. 1993 Oct ; 13 (10). 6336-45
Hiebert SW , Regions of the retinoblastoma gene product required for its interaction with the E2F transcription f… Molecular and cellular biology. 1993 Jun ; 13 (6). 3384-91

1992

Hiebert SW , Chellappan SP , Horowitz JM , Nevins JR , The interaction of RB with E2F coincides with an inhibition of the transcriptional activity of E2F. Genes & development. 1992 Feb ; 6 (2). 177-85

1991

Mudryj M , Devoto SH , Hiebert SW , Hunter T , Pines J , Nevins JR , Cell cycle regulation of the E2F transcription factor involves an interaction with cyclin A. Cell. 1991 Jun 28; 65 (7). 1243-53