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Dysregulation of normal transcription programs plays critical roles in the development of cancer. Transcription factors and chromatin-modifying enzymes frequently mutated in cancer and epigenetic changes are also found in most types of cancer. Our lab combines cutting edge technologies such as CRISPR-directed homology-directed DNA repair to modify the endogenous alleles of transcription factors and chromatin-modifying enzymes to enable deep genomic and proteomic analysis to uncover the transcriptional control circuits that control cancer development. Paired with our expertise in developing mouse models of cancer, these studies will improve our understanding of the basic biology underlying the regulation of transcription and will lead to the identification of novel therapeutic targets for the treatment of cancer.