Heterotrimeric G protein activation by G-protein-coupled receptors.
AUTHORS
Oldham
WMWilliam M ,
Hamm
HE Heidi E .
Nature reviews. Molecular cell biology. 2008 1 ; 9(1).
60-71
- PMID: 18043707[PubMed].
ABSTRACT
Heterotrimeric G proteins have a crucial role as molecular switches in signal transduction pathways mediated by G-protein-coupled receptors. Extracellular stimuli activate these receptors, which then catalyse GTP-GDP exchange on the G protein alpha-subunit. The complex series of interactions and conformational changes that connect agonist binding to G protein activation raise various interesting questions about the structure, biomechanics, kinetics and specificity of signal transduction across the plasma membrane.