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Our research program aims to reveal the impact of mitochondrial biology and function in regulating cell fate.  The lab focuses on the following lines of research:

  1. Elucidating the role of the BCL-2 family of proteins modulating mitochondrial morphology/function and in stem cell self-renewal, pluripotency, and differentiation
  2. Examining the impact of the dynamic properties of the mitochondria (fission, fusion, motility, and mitophagy) in early human cortical development using iPSC 2D and 3D model systems
  3. Examining the role of MCL-1 regulating cristae structure in human neural cells – interaction with MICOS complex and how disruption of these interactions could lead to neurodevelopmental defects

 

Welcome new IGP and QCB graduate students!  If you are interested in learning more about our research and talking about possible rotation projects, feel free to contact Dr. Gama: vivian.gama@vanderbilt.edu to schedule a Zoom meeting.