Biogenesis, delivery, and function of extracellular RNA
AUTHORS
Patton
JGJames G ,
Franklin
JLJeffrey L ,
Weaver
AMAlissa M ,
Vickers
KKasey ,
Zhang
BBing ,
Coffey
RJRobert J ,
Ansel
KMK Mark ,
Blelloch
RRobert ,
Goga
AAndrei ,
Huang
BBo ,
L'Etoille
NNoelle ,
Raffai
RLRobert L ,
Lai
CPCharles P ,
Krichevsky
AMAnna M ,
Mateescu
BBogdan ,
Greiner
VJVanille J ,
Hunter
CCraig ,
Voinnet
OOlivier ,
McManus
MTMichael T .
Journal of extracellular vesicles. 2015 08 28; 4().
27494
- PMID: 26320939[PubMed].
- PMCID: PMC4553266.
ABSTRACT
The Extracellular RNA (exRNA) Communication Consortium was launched by the National Institutes of Health to focus on the extent to which RNA might function in a non-cell-autonomous manner. With the availability of increasingly sensitive tools, small amounts of RNA can be detected in serum, plasma, and other bodily fluids. The exact mechanism(s) by which RNA can be secreted from cells and the mechanisms for the delivery and uptake by recipient cells remain to be determined. This review will summarize current knowledge about the biogenesis and delivery of exRNA and outline projects seeking to understand the functional impact of exRNA.