New Article in NATURE REVIEWS BIOENGINEERING
Research summary:
In the search for deeper insights into the molecular mechanisms of human diseases, the challenges of capturing the complex and dynamic interplay between cells and their environment remain a pressing concern. While current biological studies often focus on constant environmental conditions, the reality is that the gradual exposure of humans to harmful environmental conditions can have profound effects on signal transduction and gene regulatory pathways, contributing to disease pathogenesis. Moreover, the variability in disease outcomes and response to treatment among individuals with the same condition underscores the need for a more nuanced and single-cell approach to disease research.
To address these limitations, the Neuert lab has set out to shed light on the fundamental mechanisms of signal transduction and gene expression in normal and disease physiology in the context of gradual and physiologically relevant environmental changes and single-cell variability. Employing a quantitative framework to explore a range of biological questions in model organisms and healthy and diseased tissue, the lab integrates a suite of cutting-edge techniques, including single-cell, single-molecule, and genome-wide approaches, with computational data analysis, genetics, molecular biology, chemical profiling, and single-cell predictive computational modeling.
In the course of these endeavors, the lab has made significant strides in uncovering novel discoveries, which are detailed in its research section and publications. Key questions of interest to the lab include:
How do individual cells perceive physiologically relevant environments?
How do proteins generate dynamic behavior within a single cell?
How do cells regulate coding and non-coding genes in physiologically relevant dynamic and stochastic environments?
And how can single-cell behavior be computationally modeled and predicted to yield novel biological insights into both normal and mutated cells?
As evidenced by its commitment to Diversity, Equity, and Inclusion, the Neuert lab provides a welcoming and supportive mentoring environment for researchers from all backgrounds. Through its innovative and multi-disciplinary approach to disease research, the lab is poised to make significant contributions to the field, providing new avenues for improving human health in the years to come.
Presentations
August 2023 – Gregor will present at the Center for Quantitative Systems Biology, Vanderbilt University
June 2023 – Gregor will present at the EMBO Workshop, X-chromosome inactivation: New insights on its 60th anniversary, Berlin, Germany
May 2023 – Gregor will present in the Immunology Seminar series at the Ruhr University Bochum, Germany
April 2023 – Gregor will present in the Biological Physics & Physical Biology virtual seminar series
September 2022 – Gregor will present at the virtual Signaling Dynamics Seminar Series at UC Davis, CA
July 2022 – Gregor will present at the Systems Biology of Human Disease Conference at Vanderbilt University, Nashville, TN
July 2022 – Gregor will present at the q-bio Conference at Colorado State University, Fort Collins, CO
March 2022 – Blythe will present at the Cold Spring Harbor Meeting on Systems Biology: Global Regulation of Gene Expression in Cold Spring Harbor.
August 2021 – Hossein, Jason and Gregor will present at the Finding Your Inner Modeler IV – virtual Workshop at UIC Chicago, IL –
July 2021 – Gregor will present at the virtual q-bio summer school at the Colorado State University, Fort Collins, CO
July 2021 – Gregor will present at the virtual Signaling Dynamics Seminar Series at UC Davis, CA
May 2021 – Hossein and Gregor present at the Cold Spring Harbor Meeting on Cell Dynamics and Modeling in Cold Spring Harbor
May 2021 – Gregor presents at the NIH Systems Biology Interest Group (virtually)
March 2021 – Gregor presents at the Physics Colloquium at the University of Minnesota
News
February 2024: Check out our Vanderbilt News article on Rethinking drug efficacy
February 2024: We got funded through the NSF’s Innovation Corps (I-Corps™) program.
February 2024: Checkout our new review paper in Nature Reviews Bioengineering
September 2023: Jason won the MPB retreat best poster prize!
July 2023: Welcome Catherine Leasure as an ASPIRE Postdoctoral Fellow to our lab!
March 2023: Checkout our new review paper in Frontiers in Cell and Developmental Biology.
October 2022: Welcome Victoria to her rotation.
May 2022 – John Adams joins our lab as a Research Technician!
March 2022 – Welcome Claire to her rotation.
November 2021 – Checkout out our research involvement in the newest issue of Vestigo.
July 2021 – Our 2018 PNAS paper got selected as a highly cited paper by VUBS.
July 2021 – Our paper got accepted in STAR protocols
July 2021 – Our R01 got funded.
May 2021 – Abraheem was selected for an MB training grant slot.
May 2021 – Blythe was selected for an ITED training grant slot.
April 2021 – Abraheem Khouqeer joins our lab as a graduate student!
April 2021 – Vanderbilt News covers our recent papers!
March 2021 – Welcome Abraheem to his rotation.
February 2021 – Checkout our new paper in Science Advances. Congrats Alexander!
February 2021 – Gregor has been recognized as School of Medicine Basic Sciences Dean’s Faculty Fellow.
Funding and Support
National Institute of General Medical Sciences (NIGMS)
National Cancer Institute (NCI)
American Heart Association (AHA)
Interdisciplinary Graduate Program (IGP)
Quantitative and Chemical Biology program (QCB)
Biomedical Engineering graduate program (BME)
Chemical and Physical Biology graduate program (CPB)
Molecular Physiology and Biophysics graduate program (MPB)
Medical Scientist Training Program (MSTP)
Biomedical Informatics graduate program