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Synthesis and SAR of a novel positive allosteric modulator (PAM) of the metabotropic glutamate receptor 4 (mGluR4).


AUTHORS

Williams RRichard , Johnson KA Kari A , Gentry PR Patrick R , Niswender CM Colleen M , Weaver CD Charles D , Conn PJ P Jeffrey , Lindsley CW Craig W , Hopkins CR Corey R . Bioorganic & medicinal chemistry letters. 2009 9 1; 19(17). 4967-70

ABSTRACT

This Letter describes the synthesis and SAR of the novel positive allosteric modulator, VU0155041, a compound that has shown in vivo efficacy in rodent models of Parkinson’s disease. The synthesis takes advantage of an iterative parallel synthesis approach to rapidly synthesize and evaluate a number of analogs of VU0155041.


This Letter describes the synthesis and SAR of the novel positive allosteric modulator, VU0155041, a compound that has shown in vivo efficacy in rodent models of Parkinson’s disease. The synthesis takes advantage of an iterative parallel synthesis approach to rapidly synthesize and evaluate a number of analogs of VU0155041.