MAOS ls for the general synthesis and lead optimization of 3,6-disubstituted-[1,2,4]triazolo[4,3-b]pyridazines.
AUTHORS
Aldrich
LNLeslie N ,
Lebois
EP Evan P ,
Lewis
LM L Michelle ,
Nalywajko
NT Natalia T ,
Niswender
CM Colleen M ,
Weaver
CD C David ,
Conn
PJ P Jeffrey ,
Lindsley
CW Craig W .
Tetrahedron letters. 2009 1 14; 50(2).
212-215
- PMID: 22090663[PubMed].
- PMCID: PMC3214729.
- NIHMSID: NIHMS94278
ABSTRACT
General, high-yielding MAOS protocols for the expedient synthesis of functionalized 3,6-disubstituted-[1,2,4]triazolo[4,3-b]pyridazines are described amenable to an iterative analog library synthesis strategy for the lead optimization of an M1 antagonist screening hit. Optimized compounds proved to be highly selective M1 antagonists.