Synthesis and SAR of a novel positive allosteric modulator (PAM) of the metabotropic glutamate receptor 4 (mGluR4).
AUTHORS
Williams
RRichard ,
Johnson
KA Kari A ,
Gentry
PR Patrick R ,
Niswender
CM Colleen M ,
Weaver
CD Charles D ,
Conn
PJ P Jeffrey ,
Lindsley
CW Craig W ,
Hopkins
CR Corey R .
Bioorganic & medicinal chemistry letters. 2009 9 1; 19(17).
4967-70
- PMID: 19640716[PubMed].
- PMCID: PMC2752865.
- NIHMSID: NIHMS140686
ABSTRACT
This Letter describes the synthesis and SAR of the novel positive allosteric modulator, VU0155041, a compound that has shown in vivo efficacy in rodent models of Parkinson’s disease. The synthesis takes advantage of an iterative parallel synthesis approach to rapidly synthesize and evaluate a number of analogs of VU0155041.
This Letter describes the synthesis and SAR of the novel positive allosteric modulator, VU0155041, a compound that has shown in vivo efficacy in rodent models of Parkinson’s disease. The synthesis takes advantage of an iterative parallel synthesis approach to rapidly synthesize and evaluate a number of analogs of VU0155041.