Solution-phase parallel synthesis and SAR of homopiperazinyl analogs as positive allosteric modulators of mGlu₄.
AUTHORS
Cheung
YYYiu-Yin ,
Zamorano
R Rocio ,
Blobaum
AL Anna L ,
Weaver
CD C David ,
Conn
PJ P Jeffrey ,
Lindsley
CW Craig W ,
Niswender
CM Colleen M ,
Hopkins
CR Corey R .
ACS combinatorial science. 2011 3 14; 13(2).
159-65
- PMID: 21338051[PubMed].
- PMCID: PMC3057427.
- NIHMSID: NIHMS275479
ABSTRACT
Using a functional high-throughput screening (HTS) and subsequent solution-phase parallel synthesis approach, we have discovered a novel series of positive allosteric modulators for mGlu₄, a G-protein coupled receptor. This series is comprised of a homopiperazine central core. The solution-phase parallel synthesis and SAR of analogs derived from this series will be presented. This series of positive allosteric modulators of mGlu₄ provide critical research tools to further probe the mGlu₄-mediated effects in Parkinson’s disease.