Gigi Hunn
Pharmacology Gradudate Student
The goal of my project is to investigate potential treatments for Rett Syndrome, a rare neurodevelopmental disorder with severe cognitive and motor deficits. My focus will be to increase metabotropic glutamate receptor 7 expression in the brain by designing an antisense oligonucleotide that can block the binding of endogenous microRNAs, along with testing the effectiveness of positive allosteric modulators. I hope that these approaches will correct behavioral phenotypes in mouse models of Rett Syndrome.