Electrophysiology

Above: Field electrophysiology recording at the hippocampal SC-CA1 synapse. High-frequency induced long-term synaptic plasticity (LTP) is decreased in Mecp2+/- mice, which is normalized with bath application of mGlu7 PAM VU0422288. (Gogliotti et al 2017 Sci Transl Med)

Below: Spontaneous norepinephrine (NE) release is measured in vivo using fast-scan cyclic voltammetry. Decreased NE release in RTT mice is normalized with M1 PAM VU453595 treatment.