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MSRC Mass Spectrometry Research and Development

Race disparities in peptide profiles of North American and Kenyan Wilms tumor specimens.

AUTHORS

Libes JMJaime M , Seeley EH Erin H , Li M Ming , Axt JR Jason R , Pierce J Janene , Correa H Hernan , Newton M Mark , Hansen E Erik , Judd A Audra , McDonald H Hayes , Caprioli RM Richard M , Naranjo A Arlene , Huff V Vicki , O'Neill JA James A , Lovvorn HN Harold N , . Journal of the American College of Surgeons. 2014 4 ; 218(4). 707-20

ABSTRACT

Wilms tumor (WT) is the most common childhood kidney cancer worldwide and arises in children of black African ancestry with greater frequency and severity than other race groups. A biologic basis for this pediatric cancer disparity has not been previously determined. We hypothesized that unique molecular fingerprints might underlie the variable incidence and distinct disease characteristics of WT observed between race groups.

Wilms tumor (WT) is the most common childhood kidney cancer worldwide and arises in children of black African ancestry with greater frequency and severity than other race groups. A biologic basis for this pediatric cancer disparity has not been previously determined. We hypothesized that unique molecular fingerprints might underlie the variable incidence and distinct disease characteristics of WT observed between race groups.