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MSRC Mass Spectrometry Research and Development

Pragmatic pharmacology: population pharmacokinetic analysis of fentanyl using remnant samples from children after cardiac surgery.

AUTHORS

Van Driest SLSara L , Marshall MD Matthew D , Hachey B Brian , Beck C Cole , Crum K Kim , Owen J Jill , Smith AH Andrew H , Kannankeril PJ Prince J , Woodworth A Alison , Caprioli RM Richard M , Choi L Leena . British journal of clinical pharmacology. 2016 6 ; 81(6). 1165-74

ABSTRACT

One barrier contributing to the lack of pharmacokinetic (PK) data in paediatric populations is the need for serial sampling. Analysis of clinically obtained specimens and data may overcome this barrier. To add evidence for the feasibility of this approach, we sought to determine PK parameters for fentanyl in children after cardiac surgery using specimens and data generated in the course of clinical care, without collecting additional blood samples.

One barrier contributing to the lack of pharmacokinetic (PK) data in paediatric populations is the need for serial sampling. Analysis of clinically obtained specimens and data may overcome this barrier. To add evidence for the feasibility of this approach, we sought to determine PK parameters for fentanyl in children after cardiac surgery using specimens and data generated in the course of clinical care, without collecting additional blood samples.