Functional Redundancy Between Canonical Endocannabinoid Signaling Systems in the Modulation of Anxiety.
Authors
Bedse
G
Gaurav
,
Hartley
ND
Nolan D
,
Neale
E
Emily
,
Gaulden
AD
Andrew D
,
Patrick
TA
Toni A
,
Kingsley
PJ
Philip J
,
Uddin
MJ
Md Jashim
,
Plath
N
Niels
,
Marnett
LJ
Lawrence J
,
Patel
S
Sachin
.
Biological psychiatry. 2017 3 15; ().
Biological psychiatry. 2017 3 15; ().
Abstract
Increasing the available repertoire of effective treatments for mood and anxiety disorders represents a critical unmet need. Pharmacological augmentation of endogenous cannabinoid (eCB) signaling has been suggested to represent a novel approach to the treatment of anxiety disorders; however, the functional interactions between two canonical eCB pathways mediated via anandamide (N-arachidonylethanolamine [AEA]) and 2-arachidonoylglycerol (2-AG) in the regulation of anxiety are not well understood.