Skip to main content


Lawrence J. Marnett, Ph.D.
Lab Address: 854 RRB
Department of Biochemistry
Vanderbilt University School of Medicine
Nashville TN 37232-0146
E-Mail Larry Marnett

Headshot of Larry Marnett wearing eye-glasses.
Lawrence J. Marnett, Ph.D.

University Distinguished Professor Lawrence J. Marnett came to Vanderbilt in 1989. He is the Director of the A. B. Hancock, Jr. Memorial Laboratory for Cancer Research, Mary Geddes Stahlman Professor of Cancer Research, University Professor of Biochemistry and Chemistry, and Professor of Pharmacology.  Marnett received his Ph.D. in Chemistry from Duke University in 1973 and did postdoctoral work at the Karolinska Institute and Wayne State University.   He began his academic career at Wayne State University where he rose through the ranks to Professor of Chemistry.  In 1989, he moved to Vanderbilt.   Marnett’s research program focuses on the role of the enzyme cyclooxygenase-2 in cancer and inflammation as well as on the contribution of normal metabolism to the generation of DNA damage and mutation.  His group has used structure-based based approaches in conjunction with medicinal chemistry to design selective cyclooxygenase-2 inhibitors as potential anti-inflammatory, cancer preventive, and anti-angiogenic agents.

Included in the awards Marnett has received are The Wayne State University President’s Award for Excellence in Teaching, the American Cancer Society Faculty Research Award, the Sigma Xi Research Award, the Michigan Association of Governing Boards Distinguished Faculty Award, the Wayne State University Distinguished Graduate Faculty Award, an Outstanding Investigator Award from the National Cancer Institute, the Harvey Branscomb Distinguished Professorship, the Stanley Cohen Prize at Vanderbilt University, and the first Founders Award of the American Chemical Society Division of Chemical Toxicology.  He is a Fellow of the American Association for the Advancement of Science.  He is the author of over 450 research publications and 10 patents. He is the founding editor-in-chief of the American Chemical Society journal, Chemical Research in Toxicology.  Marnett served as Associate Director of Basic Research of the Vanderbilt Ingram Cancer Center from 1993-2002, became Director of the Vanderbilt Institute of Chemical Biology in 2002, and was named Associate Vice Chancellor for Research and Senior Associate Dean for Biomedical Sciences for the Vanderbilt University Medical Center in 2014.

B.S., Rockhurst College, cum laude, 1969
Ph.D., Duke University, 1973

Personal Information
Born Kansas City, Kansas
U.S. Citizen
Married, two children

Professional Positions
Research Associate, Karolinska Institutet, 1973-1974
Research Associate, Wayne State University, 1974-1975
Assistant Professor Chemistry, Wayne State University, 1975-1980
Associate Professor of Chemistry, Wayne State University, 1980-1983
Professor of Chemistry, Wayne State University, 1983-1989
Mary Geddes Stahlman Professor of Cancer Research, Professor of Biochemistry,
Professor of Chemistry, Vanderbilt University School of Medicine, 1989-present
Director, A.B. Hancock, Jr. Memorial Laboratory for Cancer Research,
Vanderbilt University School of Medicine, 1989-present
Associate Director for Basic Research Programs,
The Vanderbilt-Ingram Cancer Center, 1993-2002
Director, Vanderbilt Institute of Chemical Biology, 2002-present
Associate Vice Chancellor for Research, 2014-present
Senior Associate Dean for Biomedical Sciences, 2014-present

Scientific Societies
American Chemical Society
American Society of Biochemistry and Molecular Biology
American Association for the Advancement of Science
International Society for the Study of Xenobiotics
American Association for Cancer Research
The Society for Free Radical Biology and Medicine

Honorary Societies
Alpha Sigma Nu, Phi Lambda Upsilon, Sigma Xi

Editorial Activities
Founding Editor-in Chief, Chemical Research in Toxicology, 1987-2012
Senior Editor, Cancer Prevention Research, 2007-present
Member, Editorial Board, The Journal of Biological Chemistry, 1983-1987
Member, Editorial Board, Archives of Biochemistry and Biophysics,1984-1993
Member, Editorial Board, Cancer Research, 1985-1986
Member, Editoral Board, Free Radical Biology and Medicine, 1985-1994
Member, Editorial Board, Carcinogenesis, 1986-1988
Member, Editorial Board, Advances in Pharmacology, 1987-present
Series Co-Editor, Prostaglandins, Leukotrienes, and Cancer,
Martinus-Nijhoff Publisher, 1984-1988
Member, Editorial Board, Redox Reports, 1994-1996
Member, Editorial Board, Free Radical Research, 2000-present

Professional Activities

Visiting Professorships
Visiting Associate Professor of Biochemistry, University of Texas Health
Science Center – Dallas, 1981.
Visiting Professor/Sabbatical, University of California-Berkeley, Department of
Biochemistry, 1983
Visiting Scholar, University of Toledo, Department of Chemistry, 1986.

Review Committees
Species Comparison in Carcinogenesis Study Section (ad hoc),
National Institutes of Health, 1981
Chemical Pathology Study Section, National Institutes of Health, 1982-1985
Medical Biochemistry Study Section (ad hoc), National Institutes of Health,1988
National Institute of Environmental Health Sciences Review Committee,1993-1995
University of Pennsylvania, Pharmacology Department External Review Committee, 1995
Laboratory of Molecular Pathogenesis Site Visit, National Cancer Institute, August, 1997
American Health Foundation Cancer Center Site Visit, 1998
National Institute of Environmental Health Sciences, Division of Intramural
Research, Board of Scientific Councilors, 1999-2002, Chair, 2000-2002
Expert Panel – Flavor and Extract Manufacturers Association, 2000-present
Special Emphasis Panel – Chair, National Institutes of Health, 2002


External Advisory Committees
Eppley Institute for Cancer Research, University of Nebraska, 1985
Toxicology Program, University of California San Francisco, 1987
Program Project in Sickle Cell Biology, University of Chicago, 1992
Toxicology Center, University of Arizona, 1992-1997
Toxicology Center, M.D. Anderson Cancer Center Science Park Division,1994-1997
EPA Superfund Program, University of California, Berkeley, 1995
Marine Freshwater Biology Center, Oregon State University, 1996, 1999, 2003
EPA Superfund Program, University of California, San Diego, 1999
Huntsman Cancer Institute, University of Utah, 2000
Program Project “Regulation of Cell Growth and
Death by Lipid Messengers,” University of Utah, 2000
Program Project “Novel Strategies for Chemoprotection Against Cancer,”
Johns Hopkins School of Public Health, 2000
Program Project “The Impact of Smoking on Lung Cancer Chemoprevention,”
The University of Texas M.D. Anderson Cancer Center, 2001-present
Environmental Health Sciences Center, Massachusetts Institute of
Technology, 2002-present