Md. Jashim Uddin
Associate Professor of Research, Biochemistry
Jashim Uddin is interested in the development of technologies for diagnostic and therapeutic targeting of disease-associated enzymes and receptors in inflammation and carcinogenesis. The disease-associated molecular targets include cyclooxygenase isozymes (such as, COX-1 and COX-2), aldo-keto reductases (such as, AKR-1C3), and hypoxia-inducible factor 1-alpha (HIF-1-alpha), vascular endothelial growth factor receptors (such as, VEGFR-2). The disease sites include head and neck, intestine and colon, breast, and eye. The laboratory uses synthetic medicinal and protein chemistry, drug discovery, and cellular, molecular and structural biology approaches to develop target-specific imaging agents for early detection for human cancers, and targeted delivery of chemotherapeutic drugs for effective treatment of cancer.