Saturation mutagenesis of a predicted ancestral Syk-family kinase
Helen T Hobbs, Neel H Shah, Sophie R Shoemaker, Jeanine F Amacher, Susan Marqusee, and John Kuriyan

Protein Science 2022 31(10):e4411.  doi: 10.1002/pro.4411

BioRχiv 2022.04.24.489292; doi: https://doi.org/10.1101/2022.04.24.489292

A two-component protein condensate of the EGFR cytoplasmic tail and Grb2 regulates Ras activation by SOS at the membrane
Chun-Wei Lin, Laura M Nocka, Brittany L. Stinger, Joseph B DeGrandchamp, LJ Nugent Lew, Steven Alvarez, Henry T Phan, Yasushi Kondo, John Kuriyan and Jay T Groves

Proc Natl Acad Sci USA 2022 119(19):e2122531119 https://doi.org/10.1073/pnas.2122531119

BioRχiv 2021.12.12.472247; doi: https://doi.org/10.1101/2021.12.12.472247

A saturation-mutagenesis analysis of the interplay between stability and activation in Ras
Frank Hidalgo, Laura M Nocka, Neel H Shah, Kent Gorday, Naomi R Latorraca, Pradeep Bandaru, Sage Templeton, David Lee, Deepti Karandur, Jeffery G Pelton, Susan Marqusee, David E Wemmer and John Kuriyan

eLife 2022 11:e76595
doi: https:doi.org/10.7554/eLife.76595

A molecular mechanism for the generation of ligand-dependent differential outputs by the epidermal growth factor receptor
Yongjian Huang, Jana Ognjenović, Deepti Karandur, Kate Miller, Alan Merk, Sriram Subramaniam and John Kuriyan

eLife 2021 10:e73218  doi: 10.7554/eLife.73218

BioRχiv 2020.12.08.417006; doi: https://doi.org/10.1101/2020.12.08.417006

Differences in the dynamics of the tandem-SH2 modules of the Syk and ZAP-70 tyrosine kinases
Helen T Hobbs, Neel H Shah, Jean M Badroos, Christine L Gee, Susan Marqusee and John Kuriyan

Protein Science 2021 30:2373–2384  Epub October 3  doi: 10.1002/pro.4199

BioRχiv 2021.07.20.453126;
doi:https://doi.org/10.1101/2021.07.20.453126

Allosteric communication in DNA polymerase clamp loaders relies on a critical hydrogen-bonded junction
Subu Subramanian, Kent Gorday, Kendra Marcus, Matthew R. Orellana, Peter Ren, Xiao Ran Luo, Mike O’Donnell and John Kuriyan

2021 10:e66181  doi: 10.7554/eLife.66181

BioRχiv 2020.12.31.424921;
doi:https://doi.org/10.1101/2020.12.31.424921

Breakage of the oligomeric CaMKII hub by the regulatory segment of the kinase
Deepti Karandur*, Moitrayee Bhattacharyya*, Zijie Xia*, Young Kwang Lee, Serena Muratcioğlu, Darren McAffee, Ethan D McSpadden, Baiyu Qiu, Jay T Groves, Evan R Williams and John Kuriyan

eLife 2020;9:e57784  doi: 10.7554/eLife.57784
BioRχiv 2020.04.15.043067; doi: https://doi.org/10.1101/2020.04.15.043067

CRISPR-Cas12a exploits R-loop asymmetry to form double-strand breaks
Joshua C Cofsky, Deepti Karandur, Carolyn J Huang, Isaac P Witte, John Kuriyan and Jennifer A Doudna

eLife 2020;9:e55143  doi: 10.7554/eLife.55143

Flexible linkers in CaMKII control the balance between activating and inhibitory autophosphorylation
Moitrayee Bhattacharyya, Young Kwang Lee, Serena Muratcioğlu, Baiyu Qiu, Priya Nyayapati, Howard Schulman, Jay T Groves and John Kuriyan

eLife 2020;9:e53670  doi: 10.7554/eLife.53670

Cryo-EM structure of a dimeric B-Raf:14-3-3 complex reveals asymmetry in the active sites of B-Raf kinases
Yasushi Kondo*, Jana Ognjenović*, Saikat Banerjee, Deepti Karandur, Alan Merk, Kayla Kulhanek, Kathryn Wong, Jeroen P. Roose, Sriram Subramaniam and John Kuriyan

Science 2019 366:109–115  Epub Sep 19
doi: https://www.science.org/doi/10.1126/science.aay0543

Switch-like activation of Bruton’s tyrosine kinase by membrane-mediated dimerization
Jean K Chung*, Laura M Nocka*, Aubrianna Decker, Qi Wang, Theresa A Kadlecek, Arthur Weiss, John Kuriyan and Jay T. Groves

Proc Natl Acad Sci USA 2019 116(22):10798-10803
doi: https://doi.org/10.1101/284000

BioRχiv 284000; doi: https://doi.org/10.1101/284000

Variation in assembly stoichiometry in non-metazoan homologs of the hub domain of Ca2+/Calmodulin-dependent protein kinase II
Ethan D McSpadden, Zijie Xia, Chris C Chi, Anna C Susa, Neel H Shah, Christine L Gee, Evan R Williams and John Kuriyan

Protein Science 2019 28:1071–1082  Epub Apr 3  doi: https://doi.org/10.1002/pro.3614

BioRχiv 536094; doi: https://doi.org/10.1101/536094

Deep mutational analysis reveals functional trade-offs in the sequences of EGFR autophosphorylation sites
Aaron C Cantor, Neel H Shah and John Kuriyan

Proc Natl Acad Sci USA 2018 115(31):E7303-E7312  Epub July 16
doi: https://doi.org/10.1073/pnas.1803598115

BioRχiv 273516; doi: https://doi.org/10.1101/273516

Fine-tuning of substrate preferences of the Src-family kinase Lck revealed through a high-throughput specificity screen
Neel H Shah, Mark Löbel, Arthur Weiss and John Kuriyan

eLife 2018;7:e35190  doi: https://doi.org/10.7554/eLife.35190

BioRχiv 250753; doi: https://doi.org/10.1101/250753

Phosphorylation Control of the Ubiquitin Ligase Cbl is Conserved in Choanoflagellates
Jeanine F Amacher, Helen T Hobbs, Aaron C Cantor, Lochan Shah, Marco-Jose Rivero,
Sarah A Mulchand and John Kuriyan

Protein Science 2018 27(5):923-932. Epub 2018 Mar 2.  doi: https://doi.org/10.1002/pro.3397

A Histidine pH sensor regulates activation of the Ras-specific guanine nucleotide exchange factor RasGRP1
Yvonne Vercoulen*, Yasushi Kondo*, Jeffrey S Iwig*, Axel B. Janssen, Katharine A White, Mojtaba Amini, Diane L Barber, John Kuriyan and Jeroen P Roose

eLife 2017;6:e29002.  doi: https://doi.org/10.7554/eLife.29002

Multiple interactions between an Arf/GEF complex and charged lipids determine activation kinetics on the membrane
Deepti Karandur*, Agata Nawrotek*, John Kuriyan and Jacqueline Cherfils

Proc Natl Acad Sci U S A 2017 Oct 24;114(43):11416-11421. Epub 2017 Sep 18.
doi: https://doi.org/10.1073/pnas.1707970114

Deconstruction of the Ras switching cycle through saturation mutagenesis
Pradeep Bandaru, Neel H Shah, Moitrayee Bhattacharyya, John P Barton, Yasushi Kondo, Joshua C Cofsky, Christine L Gee, Arup K Chakraborty, Tanja Kortemme, Rama Ranganathan and John Kuriyan

eLife 2017;6:e27810  doi: https://doi.org/10.7554/eLife.27810

Identification of inhibitors of the association of ZAP-70 with the T cell receptor
by high-throughput screen
Patrick R Visperas, Christopher G Wilson, Jonathan A Winger, Qingrong Yan, Kevin Lin, Michelle R Arkin, Arthur Weiss and John Kuriyan

SLAS Discov. 2017 Mar 1;22(3):324-331.  Epub 2016 Dec 13
doi: https://doi.org/10.1177/1087057116681407

Crystal Structure of a Ube2S-Ubiquitin Conjugate
Sonya Lorenz, Moitrayee Bhattacharyya, Christian Feiler, Michael Rape and John Kuriyan

PLoS One 2016 11(2):e0147550.  doi: 10.1371/journal.pone.0147550

Crystal structure of the FLT3 kinase domain bound to the inhibitor Quizartinib (AC220)
Julie A. Zorn, Qi Wang, Eric Fujimura, Tiago Barros and John Kuriyan

PLoS One 2015 10(4):e0121177.  doi: 10.1371/journal.pone.0121177

Analysis of the role of the C-terminal tail in the regulation of the epidermal growth factor receptor
Erika Kovacs*, Rahul Das*, Qi Wang, Timothy S. Collier, Aaron Cantor, Yongjian Huang, Kathryn Wong, Amar Mirza, Tiago Barros, Patricia Grob, Natalia Jura, Ron Bose and John Kuriyan

Mol Cell Biol. 2015 35(17):3083-102.       doi: 10.1128/MCB.00248-15.

Crystal structure of an SH2-kinase construct of c-Abl and effect of the SH2 domain on kinase activity
Sonja Lorenz, Patricia Deng, Oliver Hantschel, Giulio Superti-Furga and John Kuriyan

Biochem. J. 2015, 468(2):283-91 doi: 10.1042/BJ20141492

Autoinhibition of Bruton’s tyrosine kinase (Btk) and activation by soluble inositol hexakisphosphate
Qi Wang, Erik M Vogan, Laura M Nocka, Connor E Rosen, Julie A Zorn, Stephen C Harrison and John Kuriyan

eLife 2015 10.7554/eLife.06074  doi: 10.7554/eLife.06074

Modification by covalent reaction or oxidation of cysteine residues in the Tandem-SH2 Domains of ZAP-70 and Syk Can Block Phosphopeptide Binding
Patrick R Visperas, Jonathan A Winger, Timothy M Horton, Neel H Shah, Diane J Aum, Alyssa Tao, Tiago Barros, Qingrong Yan, Christopher G Wilson, Michelle R Arkin, Arthur Weiss and John Kuriyan

Biochem J. 2015 465(1):149-61  doi: 10.1042/BJ20140793

Activation-triggered subunit exchange between CaMKII holoenzymes facilitates the spread of kinase activity
Margaret Stratton, Il-Hyung Lee, Moitrayee Bhattacharyya, Sune M Christensen, Luke H Chao, Howard Schulman, Jay T Groves and John Kuriyan

eLife 2014 3:e01610. doi: 10.7554/eLife.01610

Structural analysis of autoinhibition in the Ras-specific exchange factor RasGRP1
Jeffrey S. Iwig, Yvonne Vercoulen, Rahul Das, Tiago Barros, Andre Limnander, Yan Che, Jeffrey G. Pelton, David E. Wemmer, Jeroen P. Roose and John Kuriyan

eLife 2013 2:e00813. doi: 10.7554/eLife.00813

A structural role for the PHP domain in E. coli DNA polymerase III
Tiago Barros*, Joel Guenther*, Brian Kelch, Jordan Anaya, Arjun Prabhakar, Mike O’Donnell, John Kuriyan and Meindert H. Lamers

BMC Struct Biol. 2013 13:8.
doi: 10.1186/1472-6807-13-8

A highly efficient peptide substrate for EGFR activates the kinase by inducing aggregation
Kate Engel, Tomoaki Sasaki, Qi Wang and John Kuriyan

Biochem J. 2013 453(3):337-44.  doi: 10.1042/BJ20130537

Structural Basis for Activation of ZAP-70 by Phosphorylation of the SH2-Kinase Linker
Qingrong Yan, Tiago Barros, Patrick R Visperas, Sebastian Deindl, Theresa A Kadlecek, Arthur Weiss and John Kuriyan

Mol Cell Biol. 2013 33(11):2188-201.  doi: 10.1128/MCB.01637-12

Conformational Coupling across the Plasma Membrane in Activation of the EGF Receptor
Nicholas F Endres*, Rahul Das*, Adam W Smith*, Anton Arkhipov, Erika Kovacs, Yongjian Huang, Jeffrey G Pelton, Yibing Shan, David E Shaw, David E Wemmer, Jay T Groves and John Kuriyan

Cell 2013 152(3):543-56.       doi: 10.1016/j.cell.2012

How a DNA polymerase clamp loader opens a sliding clamp
Brian A Kelch*, Debora L Makino*, Michael O’Donnell and John Kuriyan

Science 2011 334(6063):1675-80.
doi: 10.1126/science.1211884

A mechanism for tunable autoinhibition in the structure of a human Ca2+/calmodulin-dependent kinase II holoenzyme
Luke H Chao, Margaret M Stratton, Il-Hyung Lee, Oren S Rosenberg, Joshua Levitz, Daniel J Mandell, Tanja Kortemme, Jay T Groves, Howard Schulman and John Kuriyan

Cell 2011 146(5):732-45.  doi: 10.1016/j.cell.2011.07.038

The Mechanism of Linkage-Specific Ubiquitin Chain Elongation by a Single-Subunit E2
Katherine E Wickliffe*, Sonja Lorenz*, David E Wemmer, John Kuriyan and Michael Rape

Cell 2011 144(5):769-81.  doi: 10.1016/j.cell.2011.01.035

Intersubunit capture of regulatory segments is a component of cooperative CaMKII activation
Luke H Chao, Patricia Pellicena, Sebastian Deindl, Lauren A Barclay, Howard Schulman and John Kuriyan

Nat Struct Mol Biol. 2010 17(3):264-72.  doi: 10.1038/nsmb.1751

Role of the histone domain in the autoinhibition and activation of the Ras activator Son of Sevenless
Jodi Gureasko, Olga Kuchment, Debora Lika Makino, Holger Sondermann, Dafna Bar-Sagi and John Kuriyan

Proc Natl Acad Sci USA. 2010 107(8):3430-5.  doi: 10.1073/pnas.0913915107

Analysis of the role of PCNA-DNA contacts during clamp loading
Randall McNally, Gregory D Bowman, Eric R Goedken, Mike O’Donnell and John Kuriyan

BMC Struct. Biol. 2010 10:3.  doi: 10.1186/1472-6807-10-3

Structural analysis of the catalytically inactive kinase domain of the human EGF receptor 3
Natalia Jura, Yibing Shan, Xiaoxian Cao, David Shaw and John Kuriyan

Proc Natl Acad Sci USA 2009 106(51):21608-13.  doi: 10.1073/pnas.0912101106

Stability of an autoinhibitory interface in the structure of the tyrosine kinase ZAP-70 impacts T cell receptor response
Sebastian Deindl, Theresa A Kadlecek, Xiaoxian Cao, John Kuriyan and Arthur Weiss

Proc Natl Acad Sci USA 2009 106(49):20699–20704.  doi:10.1073/pnas.0911512106

The tyrosine kinase Csk dimerizes through its SH3 domain
Nicholas M. Levinson, Patrick R. Visperas and John Kuriyan

PLoS One 2009 4(11):e7683.  doi: 10.1371/journal.pone.0007683

Mechanism for Activation of the EGF Receptor Catalytic Domain by the Juxtamembrane Segment
Natalia Jura, Nicholas F Endres, Kate Engel, Sebastian Deindl, Rahul Das, Meindert H Lamers, David E Wemmer, Xuewu Zhang and John Kuriyan

Cell 2009 137(7):1293-307.  doi: 10.1016/j.cell.2009.04.025

The Mechanism of ATP-Dependent Primer-Template Recognition by a Clamp Loader Complex
Kyle R Simonetta, Steven L Kazmirski, Eric R Goedken, Aaron J Cantor, Brian A Kelch, Randall McNally, Steven N Seyedin, Debora L Makino, Mike O’Donnell and John Kuriyan

Cell 2009 137(4):659-71.  doi: 10.1016/j.cell.2009.03.044

Equally Potent Inhibition of c-Src and Abl by Compounds that Recognize Inactive Kinase Conformations
Markus A Seeliger, Pratistha Ranjitkar, Corynn Kasap, Yibing Shan, David E Shaw, Neil P Shah, John Kuriyan and Dustin J Maly

Cancer Res. 2009 69(6):2384-92.  doi: 10.1158/0008-5472.CAN-08-3953

The structure of the leukemia drug imatinib bound to human quinone reductase 2 (NQO2)
Jonathan A Winger, Oliver Hantschel, Giulio Superti-Furga and John Kuriyan

BMC Struct Biol. 2009 9:7.  doi: 10.1186/1472-6807-9-7

Differences in Flexibility Underlie Functional Differences in the Ras Activators Son of Sevenless and Ras Guanine Nucleotide Releasing Factor 1
Tanya S Freedman, Holger Sondermann, Olga Kuchment, Gregory D Friedland, Tanja Kortemme and John Kuriyan

Structure 2009 17(1):41-53.  doi: 10.1016/j.str.2008.11.004

The crystal structure of the catalytic domain of a eukaryotic guanylate cyclase
Jonathan A Winger, Emily R Derbyshire, Meindert H Lamers, Michael A Marletta and John Kuriyan

BMC Struct Biol. 2008 8:42.  doi: 10.1186/1472-6807-8-42

Membrane-dependent signal integration by the Ras activator Son of sevenless
Jodi Gureasko, William J Galush, Sean Boykevisch, Holger Sondermann, Dafna Bar-Sagi, Jay T Groves and John Kuriyan

Nat Struct Mol Biol. 2008 15(5):452-61.  doi: 10.1038/nsmb.1418

Structural Basis for the Recognition of c-Src by Its Inactivator Csk
Nicholas M Levinson, Markus A Seeliger, Philip A Cole and John Kuriyan

Cell 2008 134(1):124-34.  doi: 10.1016/j.cell.2008.05.051

Inhibition of the EGF receptor by binding of MIG6 to an activating kinase domain interface
Xuewu Zhang, Kerry A. Pickin, Ron Bose, Natalia Jura, Philip A. Cole, and John Kuriyan

Nature 2007 450(7170):741-4

Structural Basis for the Inhibition of Tyrosine Kinase Activity of ZAP-70
Sebastian Deindl, Theresa A Kadlecek, Tomas Brdicka, Xiaoxian Cao, Arthur Weiss and John Kuriyan

Cell 2007 129(4):735-46

c-Src Binds to the Cancer Drug Imatinib with an Inactive Abl/c-Kit Conformation and a Distributed Thermodynamic Penalty
Markus A Seeliger, Bhushan Nagar, Filipp Frank, Xiaoxian Cao, M Nidanie Henderson and John Kuriyan

Structure 2007 15(3):299-311

Protein-protein Interactions in the Allosteric Regulation of Protein Kinases
Patricia Pellicena and John Kuriyan

Curr Opin Struct Biol. 2006 16(6):702-9

A Ras-induced Conformational Switch in the Ras Activator Son of Sevenless
Tanya S Freedman*, Holger Sondermann*, Gregory D Friedland, Tanja Kortemme, Dafna Bar-Sagi, Susan Marqusee and John Kuriyan

Proc Natl Acad Sci USA 2006 103(45):16692-7

Crystal Structure of the Catalytic α Subunit of E. coli Replicative DNA Polymerase III
Meindert H Lamers, Roxana E Georgescu, Sang-Gyu Lee, Mike O’Donnell and John Kuriyan

Cell 2006 126(5):881-92

A Dimeric Kinase Assembly Underlying Autophosphorylation in the p21 Activated Kinases
Michelle Pirruccello, Holger Sondermann, Jeffrey G Pelton, Patricia Pellicena, André Hoelz, Jonathan Chernoff, David E Wemmer and John Kuriyan

J Mol Biol. 2006 361(2):312-26

An Allosteric Mechanism for Activation of the Kinase Domain of Epidermal Growth Factor Receptor
Xuewu Zhang, Jodi Gureasko, Kui Shen, Philip A Cole and John Kuriyan

Cell 2006 125(6):1137-49

A Src-Like Inactive Conformation in the Abl Tyrosine Kinase Domain
Nicholas M Levinson*, Olga Kuchment*, Kui Shen, Matthew A Young, Michael Koldobskiy, Martin Karplus, Philip A Cole and John Kuriyan

PLoS Biol. 2006 4(5):e144

Structure of the Kinase Domain of an Imatinib-Resistant Abl Mutant in Complex with the Aurora Kinase Inhibitor VX-680
Matthew A Young, Neil P Shah, Luke H Chao, Markus Seeliger, Zdravko V Milanov, William H Biggs, III, Daniel K Treiber, Hitesh K Patel, Patrick P Zarrinkar, David J Lockhart, Charles L Sawyers and John Kuriyan

Cancer Res 2006 66(2): 1007-14.  doi: 10.1158/0008-5472.CAN-05-2788

Organization of the SH3-SH2 Unit in Active and Inactive Forms of the c-Abl Tyrosine Kinase
Bhushan Nagar, Oliver Hantschel, Markus Seeliger, Jason M Davies, William I Weis, Giulio Superti-Furga and John Kuriyan

Mol Cell. 2006 21(6):787-98

Oligomerization states of the association domain and the holoenyzme of Ca2+/CaM kinase II
Oren S. Rosenberg, Sebastian Deindl, Luis R Comolli, André Hoelz, Kenneth H Downing, Angus C Nairn and John Kuriyan

FEBSJ 2006  273:682-694.  doi: 10.1111/j.1742-4658.2005.05088.x

Crystal structure of a DNA polymerase sliding clamp from a Gram-positive bacterium
Maria A Argiriadi, Eric R Goedken, Irina Bruck, Mike O’Donnell and John Kuriyan

BMC Struct Biol. 2006 6:2

Structure of the Autoinhibited Kinase Domain of CaMKII and SAXS Analysis of the Holoenzyme
Oren S. Rosenberg, Sebastian Deindl, Rou-Jia Sung, Angus C. Nairn and John Kuriyan

Cell 2005 123(5):849-60

High yield bacterial expression of active c-Abl and c-Src tyrosine kinases

Markus A. Seeliger, Matthew Young, M. Nidanie Henderson, Patricia Pellicena, David S. King, Arnold M. Falick and John Kuriyan

Protein Sci. 2005 14(12):3135-9

Computational Docking and Solution X-ray Scattering Predict a Membrane-interacting Role for the Histone Domain of the Ras-activator Son of Sevenless
Holger Sondermann, Bhushan Nagar, Dafna Bar-Sagi and John Kuriyan

Proc Natl Acad Sci USA 2005 102(46):16632-7

Out-of-plane motions in open sliding clamps: Molecular dynamics simulations of eukaryotic and archaeal proliferating cell nuclear antigen
Steven L. Kazmirski, Yanxiang Zhao, Gregory D. Bowman, Mike O’Donnell and John Kuriyan

Protein Sci. 2005 14(12):3135-9

Mapping the interaction of DNA with the Escherichia coli DNA polymerase clamp loader complex
Eric R Goedken, Steven L Kazmirski, Gregory D Bowman, Mike O’Donnell and John Kuriyan

Nat Struct Mol Biol 2005 12(2):183-90

Structural analysis of the inactive state of the Escherichia coli DNA polymerase clamp-loader complex
Steven L. Kazmirski*, Marjetka Podobnik*, Tanya F. Weitze, Mike O’Donnell and John Kuriyan

Proc Natl Acad Sci USA 2004 101(48):16750-5

Structural Analysis of Autoinhibition in the Ras Activator Son of Sevenless
Holger Sondermann*, Stephen M. Soisson*, Sean Boykevisch, Shao-Song Yang, Dafna Bar-Sagi and John Kuriyan

Cell 2004 119(3):393-405

Crystal structure of an oxygen-binding heme domain related to soluble guanylate cyclases
Patricia Pellicena, David S. Karow, Elizabeth M. Boon, Michael A. Marletta and John Kuriyan

Proc Natl Acad Sci USA. 2004 101(35):12854-9

Structural analysis of a eukaryotic sliding DNA clamp-clamp loader complex
Gregory D. Bowman, Mike O’Donnell and John Kuriyan

Nature 2004 429(6993):724-30

Fluorescence Measurements on the E. coli DNA Polymerase Clamp Loader: Implications for Conformational Changes During ATP and Clamp Binding

Eric R. Goedken, Marcia Levitus, Aaron Johnson, Carlos Bustamante, Mike O’Donnell and John Kuriyan

J Mol Biol. 2004 336(5):1047-59

Crystal structure of the chi:psi subassembly of the Escherichia coli DNA polymerase clamp-loader complex
Jacqueline M. Gulbis, Steven L. Kazmirski, Jeff Finkelstein, Zvi Kelman, Mike O’Donnell and John Kuriyan

Eur J Biochem. 2004 271(2):439-49

Tandem Histone Folds in the Structure of the N-terminal Segment of the Ras Activator Son of Sevenless
Holger Sondermann, Stephen M. Soisson, Dafna Bar-Sagi, and John Kuriyan

Structure 2003 11(12):1583-93

Crystal Structure of a Tetradecameric Assembly of the Association Domain of Ca2+/Calmodulin-Dependent Kinase II
Andre Hoelz, Angus C. Nairn and John Kuriyan

Mol Cell. 2003 11(5):1241-51

Structural evidence for feedback activation by Ras.GTP of the Ras-specific nucleotide exchange factor SOS
S. Mariana Margarit, Holger Sondermann, Brian E. Hall, Bhushan Nagar, Andre Hoelz, Michelle Pirruccello, Dafna Bar-Sagi, and John Kuriyan

Cell 2003 112(5):685-95

Nucleotide-Induced Conformational Changes in an Isolated Escherichia coli DNA Polymerase III Clamp Loader Subunit
Marjetka Podobnik, Tanya F. Weitze, Mike O’Donnell and John Kuriyan

Structure 2003 11(3):253-63

Structural Basis for the Autoinhibition of c-Abl Tyrosine Kinase
Nagar B, Hantschel O, Young MA, Scheffzek K, Veach D, Bornmann W, Clarkson B, Superti-Furga G, Kuriyan J

Cell 2003 112(6):859-71

A Myristoyl/Phosphotyrosine Switch Regulates c-Abl

Hantschel O, Nagar B, Guettler S, Kretzschmar J, Dorey K, Kuriyan J, Superti-Furga G

Cell 2003 112(6):845-57

Reinterpretation of the Dimerization Interface of the N-terminal Domains of STATs

Xiaomin Chen, Rashna Bhandari, Uwe Vinkemeier, Focco van den Akker, James E. Darnell Jr. and John Kuriyan

Protein Sci. 2003 12(2):361-5

Crystal Structures of the Kinase Domain of c-Abl in Complex with the Small Molecule Inhibitors PD173955 and STI571
Bhushan Nagar, William Bornmann, Patricia Pellicena, Thomas Schindler, Darren Veach, W. Todd Miller, Bayard Clarkson and John Kuriyan

Cancer Res. 2002 62(15):4236-43

The TGF Receptor Activation Process: An Inhibitor- to Substrate-Binding Switch
Morgan Huse, Tom W. Muir, Lan Xu, Ye-Guang Chen, John Kuriyan and Joan Massagué

Mol Cell. 2001 8(3):671-82

Mechanism of Processivity Clamp Opening by the Delta Subunit Wrench of the Clamp Loader Complex of E. coli DNA Polymerase III
David Jeruzalmi, Olga Yurieva, Yanxiang Zhao, Matthew Young, Jelena Stewart, Manju Hingorani, Mike O’Donnell and John Kuriyan

Cell 2001 106(4):417-28

Crystal Structure of the Processivity Clamp Loader Gamma Complex of E. coli DNA Polymerase III
David Jeruzalmi, Mike O’Donnell and John Kuriyan

Cell 2001 106(4):429-441