Palmitate impairs and eicosapentaenoate restores insulin secretion through regulation of SREBP-1c in pancreatic islets.
AUTHORS
Kato
TToyonori ,
Shimano
H Hitoshi ,
Yamamoto
T Takashi ,
Ishikawa
M Mayumi ,
Kumadaki
S Shin ,
Matsuzaka
T Takashi ,
Nakagawa
Y Yoshimi ,
Yahagi
N Naoya ,
Nakakuki
M Masanori ,
Hasty
AH Alyssa H ,
Takeuchi
Y Yoshinori ,
Kobayashi
K Kazuto ,
Takahashi
A Akimitsu ,
Yatoh
S Shigeru ,
Suzuki
H Hiroaki ,
Sone
H Hirohito ,
Yamada
N Nobuhiro .
Diabetes. 2008 9 ; 57(9).
2382-92
- PMID: 18458149[PubMed].
- PMCID: PMC2518489.
ABSTRACT
Chronic exposure to fatty acids causes beta-cell failure, often referred to as lipotoxicity. We investigated its mechanisms, focusing on contribution of SREBP-1c, a key transcription factor for lipogenesis.