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Palmitate impairs and eicosapentaenoate restores insulin secretion through regulation of SREBP-1c in pancreatic islets.


AUTHORS

Kato TToyonori , Shimano H Hitoshi , Yamamoto T Takashi , Ishikawa M Mayumi , Kumadaki S Shin , Matsuzaka T Takashi , Nakagawa Y Yoshimi , Yahagi N Naoya , Nakakuki M Masanori , Hasty AH Alyssa H , Takeuchi Y Yoshinori , Kobayashi K Kazuto , Takahashi A Akimitsu , Yatoh S Shigeru , Suzuki H Hiroaki , Sone H Hirohito , Yamada N Nobuhiro . Diabetes. 2008 9 ; 57(9). 2382-92

ABSTRACT

Chronic exposure to fatty acids causes beta-cell failure, often referred to as lipotoxicity. We investigated its mechanisms, focusing on contribution of SREBP-1c, a key transcription factor for lipogenesis.