Nitro-fatty acids reduce atherosclerosis in apolipoprotein E-deficient mice.
AUTHORS
Rudolph
TKTanja K ,
Rudolph
V Volker ,
Edreira
MM Martin M ,
Cole
MP Marsha P ,
Bonacci
G Gustavo ,
Schopfer
FJ Francisco J ,
Woodcock
SR Steven R ,
Franek
A Andreas ,
Pekarova
M Michaela ,
Khoo
NK Nicholas K H ,
Hasty
AH Alyssa H ,
Baldus
S Stephan ,
Freeman
BA Bruce A .
Arteriosclerosis, thrombosis, and vascular biology. 2010 5 ; 30(5).
938-45
- PMID: 20167658[PubMed].
- PMCID: PMC2857965.
- NIHMSID: NIHMS189926
ABSTRACT
Inflammatory processes and foam cell formation are key determinants in the initiation and progression of atherosclerosis. Electrophilic nitro-fatty acids, byproducts of nitric oxide- and nitrite-dependent redox reactions of unsaturated fatty acids, exhibit antiinflammatory signaling actions in inflammatory and vascular cell model systems. The in vivo action of nitro-fatty acids in chronic inflammatory processes such as atherosclerosis remains to be elucidated.