Isoform-specific effects of apolipoprotein E on atherogenesis: gene transduction studies in mice.
AUTHORS
Yoshida
HH ,
Hasty
AH A H ,
Major
AS A S ,
Ishiguro
H H ,
Su
YR Y R ,
Gleaves
LA L A ,
Babaev
VR V R ,
Linton
MF M F ,
Fazio
S S .
Circulation. 2001 12 4; 104(23).
2820-5
- PMID: 11733401[PubMed].
ABSTRACT
We recently used a bone marrow-based gene therapy approach to show that small amounts of retrovirus-derived human apolipoprotein E3 (apoE3) produced by macrophages are protective against early atherosclerosis in apoE-deficient mice.