Direct effect of cholesterol on insulin secretion: a novel mechanism for pancreatic beta-cell dysfunction.
AUTHORS
Hao
MMingming ,
Head
WS W Steven ,
Gunawardana
SC Subhadra C ,
Hasty
AH Alyssa H ,
Piston
DW David W .
Diabetes. 2007 9 ; 56(9).
2328-38
- PMID: 17575085[PubMed].
ABSTRACT
Type 2 diabetes is often accompanied by abnormal blood lipid and lipoprotein levels, but most studies on the link between hyperlipidemia and diabetes have focused on free fatty acids (FFAs). In this study, we examined the relationship between cholesterol and insulin secretion from pancreatic beta-cells that is independent of the effects of FFAs.