Defective phagocytosis of apoptotic cells by macrophages in atherosclerotic lesions of ob/ob mice and reversal by a fish oil diet.
AUTHORS
Li
SSuzhao ,
Sun
Y Yu ,
Liang
CP Chien-Ping ,
Thorp
EB Edward B ,
Han
S Seongah ,
Jehle
AW Andreas W ,
Saraswathi
V Viswanathan ,
Pridgen
B Brian ,
Kanter
JE Jenny E ,
Li
R Rong ,
Welch
CL Carrie L ,
Hasty
AH Alyssa H ,
Bornfeldt
KE Karin E ,
Breslow
JL Jan L ,
Tabas
I Ira ,
Tall
AR Alan R .
Circulation research. 2009 11 20; 105(11).
1072-82
- PMID: 19834009[PubMed].
- PMCID: PMC2818555.
- NIHMSID: NIHMS161349
ABSTRACT
The complications of atherosclerosis are a major cause of death and disability in type 2 diabetes. Defective clearance of apoptotic cells by macrophages (efferocytosis) is thought to lead to increased necrotic core formation and inflammation in atherosclerotic lesions.