Adiposity, immunity, and inflammation: interrelationships in health and disease: A report from 24th annual Harvard nutrition obesity symposium, June 2023

AUTHORS

Burak M. Furkan , Stanley Takara L. , Lawson Elizabeth A. , Campbell Sophia L. , Lynch Lydia , Hasty Alyssa H. , Ana I. Ana I. , Dixit Vishwa D. , Hotamışlıgil Gökhan S. , Sheedy Frederick J. , Dixon Anne E. , Brinkley Tina E. , Hill Joseph A. , Donath Marc Y. , Grinspoon Steven K. .

PMID: 38705359[PubMed].

ABSTRACT

The rapidly evolving field of immunometabolism explores how changes in local immune environments may affect the key metabolic and cellular processes, including that of adipose tissue. Importantly, these changes may contribute to low-grade systemic inflammation. In turn, chronic low-grade inflammation affecting adipose tissue may exacerbate the outcome of metabolic diseases. Novel advances in our understanding of immune-metabolic processes may critically lead to interventions to reduce disease severity and progression. An important example in this regard relates to obesity, which has a multifaceted effect on immunity activating the pro-inflammatory pathways such as inflammasome and disrupting cellular homeostasis. This multifaceted effect of obesity can be investigated through study of downstream conditions using cellular and systemic investigative techniques. To further explore this field, the NIH P30 Nutrition Obesity Research Center at Harvard in partnership with the Harvard Medical School assembled experts to present at its 24^th annual Symposium entitled “Adiposity, Immunity, and Inflammation: Interrelationships in Health and Disease on June 07, 2023. This manuscript seeks to synthesize and present key findings from the symposium highlighting new research and novel disease-specific advances in the field. Better understanding the interaction between metabolism and immunity offers promising preventative and treatment therapies for obesity-related immunometabolic diseases.