Aberrant accumulation of undifferentiated myeloid cells in the adipose tissue of CCR2-deficient mice delays improvements in insulin sensitivity.
AUTHORS
Gutierrez
DADario A ,
Kennedy
A Arion ,
Orr
JS Jeb S ,
Anderson
EK Emily K ,
Webb
CD Corey D ,
Gerrald
WK William K ,
Hasty
AH Alyssa H .
Diabetes. 2011 11 ; 60(11).
2820-9
- PMID: 21926275[PubMed].
- PMCID: PMC3198070.
ABSTRACT
Mice with CCR2 deficiency are protected from insulin resistance but only after long periods of high-fat diet (HFD) feeding, despite the virtual absence of circulating inflammatory monocytes. We performed a time course study in mice with hematopoietic and global CCR2 deficiency to determine adipose tissue-specific mechanisms for the delayed impact of CCR2 deficiency on insulin resistance.