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Eugenia Gurevich Lab

Parkinsonism & related disorders

AUTHORS

Guigoni CC , Aubert I I , Li Q Q , Gurevich VV V V , Benovic JL J L , Ferry S S , Mach U U , Stark H H , Leriche L L , Håkansson K K , Bioulac BH Bernard H , Gross CE Christian E , Sokoloff P Pierre , Fisone G Gilberto , Gurevich EV E V , Bloch B Bertrand , Bezard E Erwan . Parkinsonism & related disorders. 2005 6 ; 11 Suppl 1(). S25-9

ABSTRACT

Involuntary movements, or dyskinesia, represent a debilitating complication of levodopa therapy for Parkinson’s disease. Taking advantage of a monkey brain bank constituted to study the pathophysiology of levodopa-induced dyskinesia, we here report the changes affecting D1, D2 and D3 dopamine receptors within the striatum of four experimental groups of non-human primates: normal, parkinsonian, parkinsonian treated with levodopa without or with dyskinesia. We also report the possible role of arrestin and G protein-coupled receptor kinases.

Involuntary movements, or dyskinesia, represent a debilitating complication of levodopa therapy for Parkinson’s disease. Taking advantage of a monkey brain bank constituted to study the pathophysiology of levodopa-induced dyskinesia, we here report the changes affecting D1, D2 and D3 dopamine receptors within the striatum of four experimental groups of non-human primates: normal, parkinsonian, parkinsonian treated with levodopa without or with dyskinesia. We also report the possible role of arrestin and G protein-coupled receptor kinases.