A small part of myosin IIB takes on a big role in cell polarity.
AUTHORS
Fenix
AMAidan M ,
Burnette
DT Dylan T .
The Journal of cell biology. 2015 4 13; 209(1).
11-2
- PMID: 25869662[PubMed].
- PMCID: PMC4395479.
ABSTRACT
A migrating cell must establish front-to-back polarity in order to move. In this issue, Juanes-Garcia et al. (2015. J. Cell Biol. http://dx.doi.org/10.1083/jcb.201407059) report that a short serine-rich motif in nonmuscle myosin IIB is required to establish the cell’s rear. This motif represents a new paradigm for what determines directional cell migration.
A migrating cell must establish front-to-back polarity in order to move. In this issue, Juanes-Garcia et al. (2015. J. Cell Biol. http://dx.doi.org/10.1083/jcb.201407059) report that a short serine-rich motif in nonmuscle myosin IIB is required to establish the cell’s rear. This motif represents a new paradigm for what determines directional cell migration.