Cellular contractile forces generated by the molecular motor, myosin II, drive organismal development, muscle contraction, and the progression of force dependent diseases such as cancer and cardiomyopathy. Myosin II molecules oligomerize to assemble filaments capable of pulling on actin to generate contractile forces. The Burnette lab is currently focused on two areas. First, we are interested in how non-myosin II filaments drive cytokinesis at the end of mitosis. Secondly, we are investigating how muscle myosin II filaments assemble to create the core of the sarcomere within heart muscle cells.
Contact Dylan directly for more information on specific projects if you are interested in doing a rotation (1st year Vanderbilt graduate students) or looking for a post-doctoral position.