Burnette Lab

Thesis Title: Role of Mechanical Forces in Mitosis and Heart Muscle

Burnette Lab Publications:

2016   Fenix AM, Taneja N, Buttler CA, Lewis J, Van Engelenburg SB, Ohi R, Burnette DT. Expansion and concatenation of non-muscle myosin IIA filaments drive cellular contractile system formation during interphase and mitosis. Molecular Biology of the Cell. mbc.E15-10-0725; First Published on March 9. Highlighted in Faculty Opinions

2016   Taneja N, Fenix AM, Rathbun L, Millis BA, Tyska MJ, Hehnly H, Burnette DT. Focal adhesions control cleavage furrow shape and spindle tilt during mitosis. Scientific Reports. Jul 19;6:29846.

2018   Fenix AM, Neininger AC, Taneja N, Hyde K, Visetsouk MR, Garde RJ, Liu B, Nixon BR, Manalo AE, Becker JR, Crawley SW, Bader DM, Tyska MJ, Liu Q, Gutzman JH, Burnette DT. Muscle-specific stress fibers give rise to sarcomeres in cardiomyocytes. eLife. Dec 12;7. pii: e42144.

2019   Taneja N and Burnette DT. Myosin IIA drives membrane bleb retraction. Molecular Biology of the Cell. Feb 20:mbcE18110752. doi: 10.1091/mbc.E18-11-0752.

2020   Taneja N, Bersi MR, Baillargeon SM, Fenix AM, Cooper JA, Ohi R, Gama V, Merryman WD, Burnette DT. Precise tuning of cortical contractility regulates cell shape during cytokinesis. Cell Reports. Apr 7;31(1):107477. Highlighted in Faculty Opinions

2020   Rasmussen ML*, Taneja N*, Neininger AC, Wang L, Robertson G, Riffle S, Shi L, Knollmann BC, Burnette DT, Gama V. MCL-1 inhibition by selective BH3 mimetics disrupts mitochondrial dynamics causing loss of viability and functionality of human cardiomyocytes. iScience. Mar 30;23(4):101015. * denotes equal contributions

2020   Taneja N*, Neininger AC*, Burnette DT. Coupling to substrate adhesions drives the maturation of muscle stress fibers into myofibrils within cardiomyocytes. Molecular Biology of the Cell. Jun 1;31(12):1273-1288.* denotes equal contributions

2020   Taneja N, Bersi MR, Rasmussen ML, Gama V, Merryman WD, Burnette DT. Inhibition of focal adhesion kinase increases myofibril viscosity in cardiac myocytes. Cytoskeleton (Hoboken). 2020 Sep 4. doi: 10.1002/cm.21632.

2021   Zhang Q, Jeppesen DK, Higginbotham JN, Graves-Deal R, Trinh VQ, Ramirez MA, Sohn Y, Neininger AC, Taneja N, McKinley ET, Niitsu H, Cao Z, Evans R, Glass SE, Ray KC, Fissell WH, Hill S, Rose KL, Huh WJ, Washington MK, Ayers GD, Burnette DT, Sharma S, Rome LH, Franklin JL, Lee YA, Liu Q, Coffey RJ. Supermeres are functional extracellular nanoparticles replete with disease biomarkers and therapeutic targets. Nature Cell Biology. 2021 Dec 9. doi: 10.1038/s41556-021-00805-8. Online ahead of print. PMID: 34887515

2022   Pittman M, Iu E,  Li D, Wang M, Chen J, Taneja N, Hyun Jo M, Park S, Jung WH, Liang L, Barman I, Ha T, Gaitanaros S, Liu J*, Burnette DT*, Plotnikov S*, Chen Y*. Membrane ruffling is a mechanosensor of extracellular fluid viscosity.Nature Physics. 25 July. * To whom correspondence should be addressed