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Welcome to the Constantinidis lab!

Our goal is to understand how neuronal activity in the cerebral cortex gives rise to cognitive functions. We address this question through designing acquiring neurophysiological recordings and imaging, and computational analysis of the results. Our work relies primarily on non-human primate models, but we aim to translate knowledge gained from these experiments for the benefit of human conditions in which cognitive functions have been compromised.

Positions available.

Contact us: christos.constantinidis.1@vanderbilt.edu

 

 

Cognitive Development in Adolescence

Deep-Brain Stimulation

Neural basis of working memory

Our laboratory has been investigating the changes in cognitive ability and the anatomical and neurophysiological changes that occur between the time of puberty and adulthood using a non-human primate model. Intermittent electrical stimulation of the Nucleus Basalis of Meynert can improve cognitive performance. Such Deep Brain Stimulation holds promise for conditions such as Alzheimer’s disease, and age-related dementia. Working memory is limited to a handful of items. Recordings with arrays of microelectrodes as subjects perform working memory tasks allow us to investigate the neural basis of this cognitive function and how it can be improved.