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Role of Striatal Direct Pathway 2-Arachidonoylglycerol Signaling in Sociability and Repetitive Behavior.


Shonesy BCBrian C , Parrish WPWalker P , Haddad HKHala K , Stephenson JRJason R , Báldi RRita , Bluett RJRebecca J , Marks CRChristian R , Centanni SWSamuel W , Folkes OMOakleigh M , Spiess KKeeley , Augustin SMShana M , Mackie KKen , Lovinger DMDavid M , Winder DGDanny G , Patel SSachin , Colbran RJRoger J . Biological Psychiatry. 2017 12 28; ().


Endocannabinoid signaling plays an important role in regulating synaptic transmission in the striatum, a brain region implicated as a central node of dysfunction in autism spectrum disorder. Deficits in signaling mediated by the endocannabinoid 2-arachidonoylglycerol (2-AG) have been reported in mouse models of autism spectrum disorder, but a causal role for striatal 2-AG deficiency in phenotypes relevant to autism spectrum disorder has not been explored.