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CaMKII, an emerging molecular driver for calcium homeostasis, arrhythmias, and cardiac dysfunction.


Grueter CEChad E , Colbran RJ Roger J , Anderson ME Mark E . Journal of molecular medicine (Berlin, Germany). 2007 1 ; 85(1). 5-14


Maintenance of cytoplasmic calcium homeostasis is critical for all cells. An exciting field has emerged in elucidating the multiple roles that Ca(2+)/calmodulin-dependent protein kinase II (CaMKII) plays in regulating Ca(2+) cycling in normal cardiac myocytes and in pathophysiological states. Moreover, CaMKII was recently identified as a potential drug target in cardiac disease. This work has given us a closer view of the complexity and therapeutic possibilities of CaMKII regulation of Ca(2+) signaling in cardiac myocytes.