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Tyler Perfitt

Current Position: Postdoctoral Fellow, Rare Disease Research, Pfizer, Boston, MA


Tyler is from Evansville, IN and studied biology and Spanish at DePauw University, graduating in spring 2013. He started graduate school that fall in the IGP program, and joined the Department of Molecular Physiology and Biophysics. In the Colbran lab, he has focused on optimizing binding assays, studying CaMKII regulation of various scaffolding proteins, and generating primary neuronal cultures. Tyler’s research has been funded by an American Heart Association Predoctoral Fellowship and the Molecular Endocrinology Training Program at Vanderbilt.


Neuronal L-Type Calcium Channel Signaling to the Nucleus Requires a Novel CaMKIIα-Shank3 Interaction

CaMKIIα phosphorylation of Shank3 modulates ABI1-Shank3 interaction

A novel mechanism for Ca2+/calmodulin-dependent protein kinase II targeting to L-type Ca2+channels that initiates long-range signaling to the nucleus.

A Novel Human CAMK2A Mutation Disrupts Dendritic Morphology and Synaptic Transmission, and Causes ASD-Related Behaviors.