Role of Striatal Direct Pathway 2-Arachidonoylglycerol Signaling in Sociability and Repetitive Behavior.
AUTHORS
Shonesy
BCBrian C ,
Parrish
WPWalker P ,
Haddad
HKHala K ,
Stephenson
JRJason R ,
Báldi
RRita ,
Bluett
RJRebecca J ,
Marks
CRChristian R ,
Centanni
SWSamuel W ,
Folkes
OMOakleigh M ,
Spiess
KKeeley ,
Augustin
SMShana M ,
Mackie
KKen ,
Lovinger
DMDavid M ,
Winder
DGDanny G ,
Patel
SSachin ,
Colbran
RJRoger J .
Biological Psychiatry. 2017 12 28; ().
- PMID: 29458998[PubMed].
- PMCID: PMC6023784.
ABSTRACT
Endocannabinoid signaling plays an important role in regulating synaptic transmission in the striatum, a brain region implicated as a central node of dysfunction in autism spectrum disorder. Deficits in signaling mediated by the endocannabinoid 2-arachidonoylglycerol (2-AG) have been reported in mouse models of autism spectrum disorder, but a causal role for striatal 2-AG deficiency in phenotypes relevant to autism spectrum disorder has not been explored.