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Cortactin Facilitates Malignant Transformation of Dysplastic Cells in Gastric Cancer Development in CMGH!… Read More

Excited to welcome Dr. Kook, Associate Basic Scientist, to our team!  Her profound understanding of cell biology and specialization in molecules associated with vesicle trafficking functions in various diseases will bring a new dimension to our research. Read More

We will determine if we can predict the ability of pyrvinium to reprogram the gastric mucosa using patient-derived pre-cancer organoids.  Also, we will initiate a clinical trial to evaluate the ability of a 2-week treatment with pyrvinium to reprogram metaplasia in a high-risk diverse population at Duke University in North Carolina. Read More

Amanda, welcome to our lab!  I bet you’re going to be an amazing addition. Welcome aboard!… Read More

Our new paper entitled “Oncogenic fatty acid metabolism rewires energy supply chain in gastric carcinogenesis” has been published in Gastroenterology! https://pubmed.ncbi.nlm.nih.gov/38272100/  … Read More

We have identified a unique monounsaturated fatty acid (MUFA) which fuels dysplastic cell hyperproliferation and survival. Stearoyl-CoA desaturase 1 (SCD1), a catalytic enzyme in the synthesis of unsaturated fatty acids, is specifically upregulated in the transitioning area from metaplasia to dysplasia and strongly expressed in human gastric patient tissues with… Read More