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Welcome Seunghyi!
Aug. 6, 2025—Excited to welcome Dr. Kook, Associate Basic Scientist, to our team! Her profound understanding of cell biology and specialization in molecules associated with vesicle trafficking functions in various diseases will bring a new dimension to our research.
A new paper in 2025!
Jun. 13, 2025—Cortactin Facilitates Malignant Transformation of Dysplastic Cells in Gastric Cancer Development in CMGH!
DOD Translational Team Science Award, a new grant, funded!
Jun. 21, 2024—We will determine if we can predict the ability of pyrvinium to reprogram the gastric mucosa using patient-derived pre-cancer organoids. Also, we will initiate a clinical trial to evaluate the ability of a 2-week treatment with pyrvinium to reprogram metaplasia in a high-risk diverse population at Duke University in North Carolina. Grant funds research for therapies...
Welcome Amanda!
Apr. 18, 2024—Amanda, welcome to our lab! I bet you’re going to be an amazing addition. Welcome aboard!
A new paper in 2024!
Jan. 29, 2024—Our new paper entitled “Oncogenic fatty acid metabolism rewires energy supply chain in gastric carcinogenesis” has been published in Gastroenterology! https://pubmed.ncbi.nlm.nih.gov/38272100/
Eunyoung received a AACR-Debbie’s Dream Foundation Innovation and Discovery Grant!
Jan. 9, 2024—We have identified a unique monounsaturated fatty acid (MUFA) which fuels dysplastic cell hyperproliferation and survival. Stearoyl-CoA desaturase 1 (SCD1), a catalytic enzyme in the synthesis of unsaturated fatty acids, is specifically upregulated in the transitioning area from metaplasia to dysplasia and strongly expressed in human gastric patient tissues with dysplasia and adenocarcinoma. In this...
Welcome Anavi!
Oct. 17, 2023—We welcome Anavi, a new undergraduate in the lab! She is becoming a molecular biology expert!
Congrats to Halee!
Oct. 17, 2023—Halee successfully passed her oral qualifying exam! Great Job!
We welcome Suyeon!
Apr. 21, 2023—We welcome Suyeon, a new postdoc in the lab! She will study SPEM cell plasticity and evolution with cell biology concepts.
Eunyoung is a recipient of the Gastric Cancer Foundation Award!
Nov. 2, 2022—Foundation Awards Two $100,000 Grants to Advance Gastric Cancer Research
We welcome Hannah!
Nov. 2, 2022—Hannah is a new research assistant in our lab. She will work on our transgenic animals!
We are part of a new NCI program to study the Origins of Gastroesophageal Cancers!
Oct. 12, 2022—This NCI program (funded through RFA-CA-21-026/RFA-CA-21-027) is designed to examine and define the earliest biological changes in malignant transformation. It builds on recent molecular classifications of gastroesophageal cancers, understanding of their cancer genomics, and advances in stem cell research to decipher how these cancers initially evolve at the cellular level. The initiative addresses the complex mechanisms...
We welcome Youngwon!
Aug. 29, 2022—We welcome Youngwon, a new postdoc in the lab! He will investigate molecular mechanisms driving cell lineage diversification and evolution of dysplasia to adenocarcinoma.
New R01 awarded!
Aug. 29, 2022—The Choi lab is really excited to start a brand new, second, R01 in September! We want more postdocs! If anyone is interested in cell of origin of gastric cancer or metaplastic cell plasticity, please contact Eunyoung Choi, eunyoung.choi@vumc.org.
A big congratulations to Alexis!
Aug. 29, 2022—Alexis successfully passed her oral qualifying exam! Way to go!
One more paper in 2022!
Jun. 16, 2022—Dysplastic stem cell plasticity functions as a driving force for neoplastic transformation of pre-cancerous gastric mucosa https://www.gastrojournal.org/article/S0016-5085(22)00626-6/fulltext https://pubmed.ncbi.nlm.nih.gov/35700772/
Check this out! New paper!
May. 11, 2022—Our latest international collaborative work on the function of p57Kip2 in chief cell plasticity is just out in Cell Stem Cell. https://www.cell.com/cell-stem-cell/fulltext/S1934-5909(22)00154-0
Eunyoung is the Funderburg award 2022 recipient!
May. 4, 2022— The AGA Research Foundation awards $2.56 million in research funding
Check our our new publication!
Sep. 8, 2021—Title Chief cell plasticity is the origin of metaplasia following acute injury in the stomach mucosa Published in Gut, September 2021 DOI 10.1136/gutjnl-2021-325310 Authors Caldwell, Brianna, Meyer, Anne R, Weis, Jared A, Engevik, Amy C, Choi, Eunyoung https://gut.bmj.com/content/early/2021/09/07/gutjnl-2021-325310
We are looking for a postdoc!
Jun. 7, 2021—The Choi Lab is seeking a highly motivated, recent a PhD graduate to participate in gastric cancer research. The position will focus on To assess cellular mechanisms of de novo cancer stem cell differentiation caused by acquired mutations during carcinogenic transition between pre-cancer and cancer To assess cellular heterogeneity and plasticity of de novo cancer...
