CHOI LABORATORY
The Choi lab performs basic and pre-clinical research that combines multidisciplinary approaches to understand mechanisms of carcinogenic transition in gastric carcinogenesis using novel in vivo and in vitro models which are unique in the gastric cancer field.
We welcome Suyeon!
Apr. 21, 2023—We welcome Suyeon, a new postdoc in the lab! She will study SPEM cell plasticity and evolution with cell biology concepts.
Eunyoung is a recipient of the Gastric Cancer Foundation Award!
Nov. 2, 2022—Foundation Awards Two $100,000 Grants to Advance Gastric Cancer Research
We welcome Hannah!
Nov. 2, 2022—Hannah is a new research assistant in our lab. She will work on our transgenic animals!
We are part of a new NCI program to study the Origins of Gastroesophageal Cancers!
Oct. 12, 2022—This NCI program (funded through RFA-CA-21-026/RFA-CA-21-027) is designed to examine and define the earliest biological changes in malignant transformation. It builds on recent molecular classifications of gastroesophageal cancers, understanding of their cancer genomics, and advances in stem cell research to decipher how these cancers initially evolve at the cellular level. The initiative addresses the complex mechanisms...
We welcome Youngwon!
Aug. 29, 2022—We welcome Youngwon, a new postdoc in the lab! He will investigate molecular mechanisms driving cell lineage diversification and evolution of dysplasia to adenocarcinoma.
New R01 awarded!
Aug. 29, 2022—The Choi lab is really excited to start a brand new, second, R01 in September! We want more postdocs! If anyone is interested in cell of origin of gastric cancer or metaplastic cell plasticity, please contact Eunyoung Choi, eunyoung.choi@vumc.org.
A big congratulations to Alexis!
Aug. 29, 2022—Alexis successfully passed her oral qualifying exam! Way to go!
One more paper in 2022!
Jun. 16, 2022—Dysplastic stem cell plasticity functions as a driving force for neoplastic transformation of pre-cancerous gastric mucosa https://www.gastrojournal.org/article/S0016-5085(22)00626-6/fulltext https://pubmed.ncbi.nlm.nih.gov/35700772/
Check this out! New paper!
May. 11, 2022—Our latest international collaborative work on the function of p57Kip2 in chief cell plasticity is just out in Cell Stem Cell. https://www.cell.com/cell-stem-cell/fulltext/S1934-5909(22)00154-0
Eunyoung is the Funderburg award 2022 recipient!
May. 4, 2022— The AGA Research Foundation awards $2.56 million in research funding
Check our our new publication!
Sep. 8, 2021—Title Chief cell plasticity is the origin of metaplasia following acute injury in the stomach mucosa Published in Gut, September 2021 DOI 10.1136/gutjnl-2021-325310 Authors Caldwell, Brianna, Meyer, Anne R, Weis, Jared A, Engevik, Amy C, Choi, Eunyoung https://gut.bmj.com/content/early/2021/09/07/gutjnl-2021-325310
We are looking for a postdoc!
Jun. 7, 2021—The Choi Lab is seeking a highly motivated, recent a PhD graduate to participate in gastric cancer research. The position will focus on To assess cellular mechanisms of de novo cancer stem cell differentiation caused by acquired mutations during carcinogenic transition between pre-cancer and cancer To assess cellular heterogeneity and plasticity of de novo cancer...