Eunyoung received a AACR-Debbie’s Dream Foundation Innovation and Discovery Grant!

Posted by Eunyoung Choi on Tuesday, January 9, 2024 in Uncategorized.

We have identified a unique monounsaturated fatty acid (MUFA) which fuels dysplastic cell hyperproliferation and survival. Stearoyl-CoA desaturase 1 (SCD1), a catalytic enzyme in the synthesis of unsaturated fatty acids, is specifically upregulated in the transitioning area from metaplasia to dysplasia and strongly expressed in human gastric patient tissues with dysplasia and adenocarcinoma.

In this project, we seek to evaluate the potential of aberrant fatty acid metabolism as a novel druggable target for prevention or treatment of gastric cancer by assessing levels of MUFA metabolites in human tissues and determine the efficacy of SCD1-targeting drugs.

 

AACR-Debbie’s Dream Foundation Innovation and Discovery Grant