Center for Cancer Systems Biology

Jonathan M. Lehman, M.D., Ph.D., is a physician scientist with a research focus on SCLC. One of his original contributions in this field is the emphasis on the underappreciated role of metabolism in SCLC and SSTR2 signaling with its influence on AMPKa phosphorylation in metabolic flux and survival. Jon’s role in the Center will encompass the characterization of SCLC phenotypes both in cell lines and PDXs that he initiates and curates. He works in close collaboration with Pierre Massion, MD, Director of Cancer Early Detection and Prevention Initiative and an expert in lung cancer.