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Bioinformatics/Computational Biology (University of Colorado)
PhD-level Bioinformatics/Computational Biologists that would be interested in leading projects through the University of Colorado Cancer Center.

The University of Colorado Comprehensive Cancer Center (UCCC) is seeking a PhD-level Bioinformatics researcher who will specialize in the analysis of –omics data. The UCCC places a strong emphasis on reproducible research, and a skillset that is compatible with reproducible data science practices is required. The ideal candidate will have a proven track record of leading the analysis of experiments using multiple -omic profiling technologies, such as whole genome/exome sequencing, ChIP-/ATAC-seq, RNAseq, proteomics, metabolomics, mass cytometry, and/or single cell technologies. The holder of this position will collaborate with UCCC investigators to lead the bioinformatics analysis of individual projects. This position will also participate in group meetings with other Bioinformaticists and occasionally present in educational seminars. An additional benefit of this position will be the ability to spend up to 25% of their time developing novel computational methods as independent research. Thus, the individual will have the opportunity to develop independence of research through individual and collaborative grant funding.
Jim Costello, PhD
Associate Professor
Department of Pharmacology
Boettcher Investigator
University of Colorado Anschutz Medical Campus
Mail Stop 8303
12801 E. 17th Ave., Rm L18-6114
Aurora, CO 80045
(303) 724-8619


The Quaranta Lab at Vanderbilt University has an opening for a post-doctoral researcher to study drug sensitivity of Small Cell Lung Cancer (SCLC) using computational and experimental approaches.

The Quaranta Lab at Vanderbilt University has an opening for a post-doctoral researcher to study drug sensitivity of Small Cell Lung Cancer (SCLC) using computational and experimental approaches.

The ideal candidate will have experience in both computation and experimentation, and demonstrate methods to connect the two. Studies will be focused on pathways that control drug sensitivity of cancer cells, with a focus on Small Cell Lung Cancer (SCLC). The candidate should ideally possess preexisting knowledge that includes, but is not restricted to the following: metabolism, programmed cell death, or the Notch signaling network. Scientific writing ability is definitely a plus; candidate must be a team player.

The Vanderbilt University Center for Cancer Systems Biology is part of the national Cancer Systems Biology Consortium. The overarching goal of our Center is to produce a quantitative understanding of plasticity and dynamics of cancer cell subtypes in SCLC, as we believe this knowledge holds the promise of major advances in treatment. Both genetic and epigenetic factors contribute to tumor heterogeneity. Furthermore, multidirectional interactions of distinct tumor cell subtypes amongst themselves and with host cells shape the evolutionary trajectory of a tumor, including its metastatic properties. Thus, heterogeneity is a complex, multi-scale problem (from genes to molecules to cells to tissues), intrinsically unsuitable to reductionist approaches. Rather, we consider a systems-level approach to current challenges, which include: 1) identifying useful quantitative metrics of a tumor phenotypic space; 2) defining deterministic and stochastic components of heterogeneity at molecular and cellular levels; 3) deriving emergent tumor subtype dynamics from single-cell behavior; and 4) designing effective treatment strategies based on this system-level knowledge.

Please e-mail inquiries to Dr. Amanda Linkous. Applicants should submit a letter of interest, curriculum vitae, and contact information for three references.
Amanda Linkous, PhD