Donahue EK, Hepowit NL, Ruark EM, Mulligan AG, Keuchel B, Urban ND, Peng L, Stephens S, Johnson DJ, Wallace N, Jackson LP, Ellisman M, Arrojo e Drigo R, Folkmann AW, Truttmann MC, MacGurn JA, Burkewitz K. ER-phagy drives age-onset remodeling of endoplasmic reticulum structure-function and lifespan. Nature Cell Biology, 28(3): 449-464. 2026.
Urban ND, Lacy SM, Van Pelt KM, Abdon B, Mattiola Z, Klaiss A, Tabler S, Donahue EKF, Burkewitz K, Truttmann MC. Functionally diversified BiP orthologs controls body growth, reproduction, stress resistance, aging, and autophagy in Caenorhabditis elegans. Nature Communications 16, 11094 (2025).
Feng G., Ruark EM, Mulligan AG, Donahue E, Jacquet-Cribe B., Burkewitz K. Inter-organelle calcium signaling mediates mitochondrial stress-induced longevity via actomyosin-based mitochondrial dynamics. BioRxiv doi: 10.1101/2025.08.30.673265.
Valera-Alberni M, Lanjuin A, Romero-Sanz S, Burkewitz K, Hughes AL, Mair WB. Nutrient-responsive formation of mitochondrial-derived structures in Caenorhabditis elegans. BioRxiv doi: 10.1101/2025.06.24
Habashy A, Acree C, Kim KY, Zahraei A, Dufresne M, Phan S, Patterson E, Mulligan A, Burkewitz K, Flyn CR, Lantier L, McGuinness OP, Spraggins J, Ellisman MH, Arrojo e Drigo R. Spatial patterns of hepatocyte glucose flux revealed by stable isotope tracing and multi-scale microscopy. Nature Communications 16, 5850 (2025).
Tsyba N, Feng G, Grub LK, Held JP, Strozak AM, Burkewitz K, Patel MR. Tissue-specific heteroplasmy segregation is accompanied by a sharp mtDNA decline in C. elegans soma. iScience 26: 106349. 2023.
Donahue EKF, Ruark EM, Burkewitz K. Fundamental roles for inter-organelle communication in aging. Biochemical Society Transactions 50(5):1389-1402. 2022.
Held JP, Feng G, Saunders BR, Pereira CV, Burkewitz K, Patel MR. A tRNA processing enzyme is a key regulator of the mitochondrial unfolded protein response. Elife 11:e71634. 2022.
Burkewitz K*, Feng G, Dutta S, Kelley CA, Steinbaugh M, Cram EJ, Mair WB*. Atf-6 regulates lifespan through ER-mitochondrial calcium homeostasis. Cell Reports 32(10):108125. 2020. *co-corresponding authors
Weir HJ, Yao P, Huynh FK, Escoubas CE, Goncalves R, Burkewitz K, Laboy R, Hirschey MD, Mair WB. Dietary Restriction and AMPK Increase Lifespan via Mitochondrial Network and Peroxisomal Remodeling. Cell Metabolism 26(6): 884-96. 2017.
Burkewitz K*, Weir HJ, Mair WB*. AMPK as a pro-longevity target, In: AMP-activated Protein Kinase, Cordero MD and Viollet B ed., Springer International Publishing, 227-256. 2016. *co-corresponding authors
Jacobi D, Liu S, Burkewitz K, Kory N, Knudsen NH, Alexander RK, Unluturk U, Li X, Kang X, Hyde A, Gangl MR, Farese RV, Walther T, Mair WB, Lee CH. Hepatic Bmal1 regulates rhythmic mitochondrial dynamics and promotes metabolic fitness. Cell Metabolism 22(4): 709-720. 2015.
Burkewitz K, Morantte I, Weir HJ, Yeo R, Zhang Y, Huynh FK, Ilkayeva OR, Hirschey MD, Grant AR, Mair WB. Neuronal CRTC-1 governs systemic mitochondrial metabolism and lifespan via a catecholamine signal. Cell 160(5): 842-55. 2015.
Burkewitz K, Zhang Y, Mair WB. AMPK at the nexus of energetics and aging. Cell Metabolism 20(1): 10-25. 2014.