Publications
2024
BrownBreann L, Heterologous Expression and Purification of Eukaryotic ALA Synthase from E. coliIron Metabolism. Methods in Molecular Biology. 2024 2839
TaylorJessica L, Ayres-GalhardoPedro H, BrownBreann L, Elucidating the role of human ALAS2 C-terminal mutations resulting in loss-of-function and diseaseBiochemistry. 2024 63 (13). 1636–1646
- PMID: 38888931[PubMed].
- PMCID: PMC11223264 .
2023
TranU, BrownL, The yeast ALA synthase C-terminus positively controls enzyme structure and functionProtein Science. 2023 32 (4).
- PMID: 36807942[PubMed].
- PMCID: PMC10031213 .
2022
TranU, BrownL, Structural Basis for Allostery in PLP-dependent EnzymesFrontiers in Molecular Biosciences. 2022 9:884281
- PMID: 35547395[PubMed].
TaylorL, BrownL, Structural basis for dysregulation of aminolevulinic acid synthase in human diseaseJournal of Biological Chemistry. 2022
- PMID: 35093382[PubMed].
2021
BrownBL, IversonTM, Handling heme with careNature Chemical Biology. 2021 17 751-752
2020
HungLY, TanakaY, HerbineK, PastoreC, SinghB, FergusonA, VoraN, DouglasB, ZulloK, BehrensEM, TanTLH, KohanskiMA, BryceP, LinC, KambayashiT, ReedDR, BrownBL, CohenNA, HerbertDR, Cellular context of IL-33 expression dictates impact on anti-helminth immunityScience Immunology. 2020 5 (53). eabc6259
2019
BrownBL, VieuxEF, KalastavadiT, KimS, ChenJZ, BakerTA, N domain of the Lon AAA+ protease controls assembly and substrate choiceProtein science : a publication of the Protein Society. 2019 Nov 21 28 (7). 1239-1251
- PMID: 30461098[PubMed].
2018
BrownBL, KardonJR, SauerRT, BakerTA, Structure of the Mitochondrial Aminolevulinic Acid Synthase, a Key Heme Biosynthetic EnzymeStructure (London, England : 1993). 2018 Mar 15 26 (4). 580-589.e4
- PMID: 29551290[PubMed].
- PMCID: PMC5894356 .
2013
DavisJR, BrownBL, PageR, SelloJK, Study of PcaV from Streptomyces coelicolor yields new insights into ligand-responsive MarR family transcription factorsNucleic acids research. 2013 Feb 8 41 (6). 3888-900
- PMID: 23396446[PubMed].
- PMCID: PMC3616709 .
2012
BrownBL, LordDM, GrigoriuS, PetiW, PageR, The Escherichia coli toxin MqsR destabilizes the transcriptional repression complex formed between the antitoxin MqsA and the mqsRA operon promoterThe Journal of biological chemistry. 2012 Nov 21 288 (2). 1286-94
- PMID: 23172222[PubMed].
- PMCID: PMC3543012 .
2011
WangX, KimY, HongSH, MaQ, BrownBL, PuM, TaroneAM, BenedikMJ, PetiW, PageR, WoodTK, Antitoxin MqsA helps mediate the bacterial general stress responseNature chemical biology. 2011 Apr 24 7 (6). 359-66
- PMID: 21516113[PubMed].
- PMCID: PMC3097263 .
2010
BrownBL, WoodTK, PetiW, PageR, Structure of the Escherichia coli antitoxin MqsA (YgiT/b3021) bound to its gene promoter reveals extensive domain rearrangements and the specificity of transcriptional regulationThe Journal of biological chemistry. 2010 Nov 9 286 (3). 2285-96
- PMID: 21068382[PubMed].
- PMCID: PMC3023523 .
BrownBL, PageR, Preliminary crystallographic analysis of the Escherichia coli antitoxin MqsA (YgiT/b3021) in complex with mqsRA promoter DNAActa crystallographica. Section F, Structural biology and crystallization communications. 2010 Aug 26 66 (Pt 9). 1060-3
- PMID: 20823526[PubMed].
- PMCID: PMC2935227 .
2009
BrownBL, GrigoriuS, KimY, ArrudaJM, DavenportA, WoodTK, PetiW, PageR, Three dimensional structure of the MqsR:MqsA complex: a novel TA pair comprised of a toxin homologous to RelE and an antitoxin with unique propertiesPLoS pathogens. 2009 Dec 24 5 (12). e1000706
- PMID: 20041169[PubMed].
- PMCID: PMC2791442 .
2008
BrownBL, HadleyM, PageR, Heterologous high-level E. coli expression, purification and biophysical characterization of the spine-associated RapGAP (SPAR) PDZ domainProtein expression and purification. 2008 Jul 18 62 (1). 9-14
- PMID: 18678258[PubMed].